We isolated cDNA encoding a novel FGF (210 amino acids) from mouse embryos. As this is the 21st documented FGF, we tentatively term it FGF-21. FGF-21 has a hydrophobic amino terminus (~30 amino acids), which is a typical signal sequence, and appears to be a secreted protein. The expression of FGF-21 mRNA in mouse adult tissues was examined by Northern blotting analysis. FGF-21 mRNA was most abundantly expressed in the liver, and also expressed in the thymus at lower levels. We also isolated human cDNA encoding FGF-21 (209 amino acids). Human FGF-21 is highly identical (~75% amino acid identity) to mouse FGF-21. Among human FGF family members, FGF-21 is most similar (~35% amino acid identity) to FGF-19. Copyright (C) 2000 Elsevier Science B.V.
|Number of pages||4|
|Journal||Biochimica et Biophysica Acta - Gene Structure and Expression|
|Publication status||Published - 2000 Jun 21|
- Fibroblast growth factor
- Gene family
ASJC Scopus subject areas
- Structural Biology