Identification of a novel fibroblast growth factor, FGF-22, preferentially expressed in the inner root sheath of the hair follicle

Yuki Nakatake, Masamitsu Hoshikawa, Toshiyuki Asaki, Yoshiaki Kassai, Nobuyuki Itoh

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

We isolated cDNA encoding a novel fibroblast growth factor (FGF-22) (170 amino acids) from human placenta. Of the FGF family members, FGF-22, which appears to be a secreted protein, is most similar to FGF-10 and FGF-7 (∼46% and ∼40% amino acid identities, respectively). The human FGF-22 gene was localized on chromosome 19p13.3. We also isolated mouse cDNA encoding FGF-22 (162 amino acids) from the skin. Mouse FGF-22 shows high homology (87% amino acid identity) to human FGF-22. Mouse FGF-22 mRNA was found to be preferentially expressed in the skin among the mouse adult tissues examined by Northern blotting analysis. By in situ hybridization, FGF-22 mRNA in the skin was found to be preferentially expressed in the inner root sheath of the hair follicle. Therefore, FGF-22 is expected to be a unique FGF that plays a role in hair development.

Original languageEnglish
Pages (from-to)460-463
Number of pages4
JournalBiochimica et Biophysica Acta - Gene Structure and Expression
Volume1517
Issue number3
DOIs
Publication statusPublished - 2001 Feb 16
Externally publishedYes

Fingerprint

Fibroblast Growth Factors
Hair Follicle
Amino Acids
Skin
Complementary DNA
Messenger RNA
Chromosomes
Northern Blotting
Hair
Placenta
In Situ Hybridization
Genes
Tissue
Proteins

Keywords

  • Fibroblast growth factor
  • Gene expression
  • Gene family
  • Growth factor
  • Hair
  • Skin

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Structural Biology
  • Biophysics

Cite this

Identification of a novel fibroblast growth factor, FGF-22, preferentially expressed in the inner root sheath of the hair follicle. / Nakatake, Yuki; Hoshikawa, Masamitsu; Asaki, Toshiyuki; Kassai, Yoshiaki; Itoh, Nobuyuki.

In: Biochimica et Biophysica Acta - Gene Structure and Expression, Vol. 1517, No. 3, 16.02.2001, p. 460-463.

Research output: Contribution to journalArticle

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