Identification of a novel human homolog of the Drosophila dlg, P-dlg, specifically expressed in the gland tissues and interacting with p55

Hideo Nakamura, Tamotsu Sudo, Hiromasa Tsuiki, Hideaki Miyake, Tetsuro Morisaki, Ji Ichiro Sasaki, Norio Masuko, Masato Kochi, Yukitaka Ushio, Hideyuki Saya

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

We have identified a novel human homolog of the Drosophila dlg tumor suppressor gene, termed P-dlg, which has been mapped at chromosome 10q23. Unlike other human dlg homologs, P-dlg is expressed in placenta and various gland tissues but not in brain. The P-dlg protein is localized at the plasma membrane and cytoplasm, and it is expressed in the gland epithelial cells in normal prostate tissue but not in prostate cancer cell lines. Furthermore, we identified interaction between P-dlg and p55 palmitoylated membrane protein by yeast two-hybrid screening. These findings suggest that P-dlg forms a complex with p55 at the plasma membrane and plays roles in maintaining the structure of epithelial cells and transmitting extracellular signals to the membrane and cytoskeleton, which may negatively regulate cell proliferation. Copyright (C) 1998 Federation of European Biochemical Societies.

Original languageEnglish
Pages (from-to)63-67
Number of pages5
JournalFEBS Letters
Volume433
Issue number1-2
DOIs
Publication statusPublished - 1998 Aug 14
Externally publishedYes

Keywords

  • Chromosome 10q23
  • MAGUK family protein
  • P-dlg
  • p55

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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    Nakamura, H., Sudo, T., Tsuiki, H., Miyake, H., Morisaki, T., Sasaki, J. I., Masuko, N., Kochi, M., Ushio, Y., & Saya, H. (1998). Identification of a novel human homolog of the Drosophila dlg, P-dlg, specifically expressed in the gland tissues and interacting with p55. FEBS Letters, 433(1-2), 63-67. https://doi.org/10.1016/S0014-5793(98)00882-5