Identification of a novel SEPT9-ABL1 fusion gene in a patient with T-cell prolymphocytic leukemia

Rikio Suzuki; Hiromochi Matsushita; Hidetsugu Kawai; Hideyuki Matsuzawa; Kosuke Tsuboi; Shigeki Watanabe; Hiroshi Kawada; Yoshiaki Ogawa; Kiyoshi Ando

doi:10.1016/j.lrr.2014.06.004

Identification of a novel SEPT9-ABL1 fusion gene in a patient with T-cell prolymphocytic leukemia

Rikio Suzuki, Hiromochi Matsushita, Hidetsugu Kawai, Hideyuki Matsuzawa, Kosuke Tsuboi, Shigeki Watanabe, Hiroshi Kawada, Yoshiaki Ogawa, Kiyoshi Ando

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

T-cell prolymphocytic leukemia (T-PLL), a rare type of peripheral T-cell leukemia, is characterized by marked splenomegaly with rapidly progressive lymphocytosis and a poor prognosis. Nine kinds of ABL1 chimeric genes have been identified in various kinds of hematological malignancies, such as chronic myeloid leukemia and B- or T-lymphoblastic leukemia. However, there have been no reports describing T-PLL cases with ABL1 rearrangements. We herein report a case of T-PLL with a novel SEPT9-. ABL1 fusion gene which induced strong resistance to tyrosine kinase inhibitors such as imatinib and dasatinib.

Original language	English
Pages (from-to)	54-57
Number of pages	4
Journal	Leukemia Research Reports
Volume	3
Issue number	2
DOIs	https://doi.org/10.1016/j.lrr.2014.06.004
Publication status	Published - 2014 Dec 1
Externally published	Yes

Keywords

SEPT9-ABL1
T-cell prolymphocytic leukemia
Tyrosine kinase inhibitors

ASJC Scopus subject areas

Hematology
Oncology

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10.1016/j.lrr.2014.06.004

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title = "Identification of a novel SEPT9-ABL1 fusion gene in a patient with T-cell prolymphocytic leukemia",

abstract = "T-cell prolymphocytic leukemia (T-PLL), a rare type of peripheral T-cell leukemia, is characterized by marked splenomegaly with rapidly progressive lymphocytosis and a poor prognosis. Nine kinds of ABL1 chimeric genes have been identified in various kinds of hematological malignancies, such as chronic myeloid leukemia and B- or T-lymphoblastic leukemia. However, there have been no reports describing T-PLL cases with ABL1 rearrangements. We herein report a case of T-PLL with a novel SEPT9-. ABL1 fusion gene which induced strong resistance to tyrosine kinase inhibitors such as imatinib and dasatinib.",

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doi = "10.1016/j.lrr.2014.06.004",

language = "English",

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T1 - Identification of a novel SEPT9-ABL1 fusion gene in a patient with T-cell prolymphocytic leukemia

AU - Suzuki, Rikio

AU - Matsushita, Hiromochi

AU - Kawai, Hidetsugu

AU - Matsuzawa, Hideyuki

AU - Tsuboi, Kosuke

AU - Watanabe, Shigeki

AU - Kawada, Hiroshi

AU - Ogawa, Yoshiaki

AU - Ando, Kiyoshi

PY - 2014/12/1

Y1 - 2014/12/1

N2 - T-cell prolymphocytic leukemia (T-PLL), a rare type of peripheral T-cell leukemia, is characterized by marked splenomegaly with rapidly progressive lymphocytosis and a poor prognosis. Nine kinds of ABL1 chimeric genes have been identified in various kinds of hematological malignancies, such as chronic myeloid leukemia and B- or T-lymphoblastic leukemia. However, there have been no reports describing T-PLL cases with ABL1 rearrangements. We herein report a case of T-PLL with a novel SEPT9-. ABL1 fusion gene which induced strong resistance to tyrosine kinase inhibitors such as imatinib and dasatinib.

AB - T-cell prolymphocytic leukemia (T-PLL), a rare type of peripheral T-cell leukemia, is characterized by marked splenomegaly with rapidly progressive lymphocytosis and a poor prognosis. Nine kinds of ABL1 chimeric genes have been identified in various kinds of hematological malignancies, such as chronic myeloid leukemia and B- or T-lymphoblastic leukemia. However, there have been no reports describing T-PLL cases with ABL1 rearrangements. We herein report a case of T-PLL with a novel SEPT9-. ABL1 fusion gene which induced strong resistance to tyrosine kinase inhibitors such as imatinib and dasatinib.

KW - SEPT9-ABL1

KW - T-cell prolymphocytic leukemia

KW - Tyrosine kinase inhibitors

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JF - Leukemia Research Reports

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ER -

Identification of a novel SEPT9-ABL1 fusion gene in a patient with T-cell prolymphocytic leukemia

Abstract

Keywords

ASJC Scopus subject areas

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