Identification of genes associated with the astrocyte-specific gene Gfap during astrocyte differentiation

Kenji Ito, Tsukasa Sanosaka, Katsuhide Igarashi, Maky Ideta-Otsuka, Akira Aizawa, Yuichi Uosaki, Azumi Noguchi, Hirokazu Arakawa, Kinichi Nakashima, Takumi Takizawa

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Abstract

Chromosomes and genes are non-randomly arranged within the mammalian cell nucleus, and gene clustering is of great significance in transcriptional regulation. However, the relevance of gene clustering and their expression during the differentiation of neural precursor cells (NPCs) into astrocytes remains unclear. We performed a genome-wide enhanced circular chromosomal conformation capture (e4C) to screen for genes associated with the astrocyte-specific gene glial fibrillary acidic protein (Gfap) during astrocyte differentiation. We identified 18 genes that were specifically associated with Gfap and expressed in NPC-derived astrocytes. Our results provide additional evidence for the functional significance of gene clustering in transcriptional regulation during NPC differentiation.

Original languageEnglish
Article number23903
JournalScientific Reports
Volume6
DOIs
Publication statusPublished - 2016 Apr 4
Externally publishedYes

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Cite this

Ito, K., Sanosaka, T., Igarashi, K., Ideta-Otsuka, M., Aizawa, A., Uosaki, Y., Noguchi, A., Arakawa, H., Nakashima, K., & Takizawa, T. (2016). Identification of genes associated with the astrocyte-specific gene Gfap during astrocyte differentiation. Scientific Reports, 6, [23903]. https://doi.org/10.1038/srep23903