Identification of licopyranocoumarin and glycyrurol from herbal medicines as neuroprotective compounds for Parkinson's disease

Takahiro Fujimaki, Shinji Saiki, Etsu Tashiro, Daisuke Yamada, Mitsuhiro Kitagawa, Nobutaka Hattori, Masaya Imoto

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In the course of screening for the anti-Parkinsonian drugs from a library of traditional herbal medicines, we found that the extracts of choi-joki-to and daio-kanzo-to protected cells from MPP+-induced cell death. Because choi-joki-to and daio-kanzo-to commonly contain the genus Glycyrrhiza, we isolated licopyranocoumarin (LPC) and glycyrurol (GCR) as potent neuroprotective principals from Glycyrrhiza. LPC and GCR markedly blocked MPP +-induced neuronal PC12D cell death and disappearance of mitochondrial membrane potential, which were mediated by JNK. LPC and GCR inhibited MPP+-induced JNK activation through the suppression of reactive oxygen species (ROS) generation, thereby inhibiting MPP +-induced neuronal PC12D cell death. These results indicated that LPC and GCR derived from choi-joki-to and daio-kanzo-to would be promising drug leads for PD treatment in the future.

Original languageEnglish
Article numbere100395
JournalPLoS One
Volume9
Issue number6
DOIs
Publication statusPublished - 2014 Jun 24

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Herbal Medicine
Parkinson disease
herbal medicines
Glycyrrhiza
Parkinson Disease
cell death
Cell death
Cell Death
neurons
drugs
membrane potential
Mitochondrial Membrane Potential
reactive oxygen species
Traditional Medicine
Pharmaceutical Preparations
Libraries
screening
Reactive Oxygen Species
Screening
Chemical activation

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Identification of licopyranocoumarin and glycyrurol from herbal medicines as neuroprotective compounds for Parkinson's disease. / Fujimaki, Takahiro; Saiki, Shinji; Tashiro, Etsu; Yamada, Daisuke; Kitagawa, Mitsuhiro; Hattori, Nobutaka; Imoto, Masaya.

In: PLoS One, Vol. 9, No. 6, e100395, 24.06.2014.

Research output: Contribution to journalArticle

Fujimaki, Takahiro ; Saiki, Shinji ; Tashiro, Etsu ; Yamada, Daisuke ; Kitagawa, Mitsuhiro ; Hattori, Nobutaka ; Imoto, Masaya. / Identification of licopyranocoumarin and glycyrurol from herbal medicines as neuroprotective compounds for Parkinson's disease. In: PLoS One. 2014 ; Vol. 9, No. 6.
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