Identification of novel non-peptide CXCR4 antagonists by ligand-based design approach

Satoshi Ueda, Manabu Kato, Shinsuke Inuki, Hiroaki Ohno, Barry Evans, Zi xuan Wang, Stephen C. Peiper, Kazuki Izumi, Eiichi Kodama, Masao Matsuoka, Hideko Nagasawa, Shinya Oishi, Nobutaka Fujii

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

The design and synthesis of novel non-peptide CXCR4 antagonists is described. The peptide backbone of highly potent cyclic peptide-based CXCR4 antagonists was entirely replaced by an indole framework, which was expected to reproduce the disposition of the key pharmacophores consistent with those of potential bioactive conformations of the original peptides. A structure-activity relationship study on a series of modified indoles identified novel small-molecule antagonists having three pharmacophore functional groups through the appropriate linkers.

Original languageEnglish
Pages (from-to)4124-4129
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number14
DOIs
Publication statusPublished - 2008 Jul 15

Keywords

  • Anti-HIV
  • CXCR4
  • Chemokine
  • Indole
  • SDF-1

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Identification of novel non-peptide CXCR4 antagonists by ligand-based design approach'. Together they form a unique fingerprint.

Cite this