Identification of novel omega-3 fatty acid-derived bioactive metabolites based on a targeted lipidomics approach

Yosuke Isobe, Makoto Arita

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Omega-3 Polyunsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid have beneficial effects in many inflammatory disorders. Although the mechanism of eicosapentaenoic acid and docosahexaenoic acid action is still not fully defined in molecular terms, recent studies have revealed that, during the course of acute inflammation, omega-3 polyunsaturated fatty acid-derived anti-inflammatory mediators including resolvins and protectins are produced. This review presents recent advances in understanding the formation and action of these mediators, especially focusing on the LC-MS/MS-based lipidomics approach and recently identified bioactive products with potent anti-inflammatory property.

Original languageEnglish
Pages (from-to)79-84
Number of pages6
JournalJournal of Clinical Biochemistry and Nutrition
Volume55
Issue number2
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

Eicosapentaenoic Acid
Docosahexaenoic Acids
Omega-3 Fatty Acids
Metabolites
Unsaturated Fatty Acids
Anti-Inflammatory Agents
CD59 Antigens
Inflammation

Keywords

  • Anti-inflammation
  • Lipid mediator
  • Metabolomics
  • Omega-3 fatty acid

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

@article{6d276e0298fa4685a2fc1c7b07ee393c,
title = "Identification of novel omega-3 fatty acid-derived bioactive metabolites based on a targeted lipidomics approach",
abstract = "Omega-3 Polyunsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid have beneficial effects in many inflammatory disorders. Although the mechanism of eicosapentaenoic acid and docosahexaenoic acid action is still not fully defined in molecular terms, recent studies have revealed that, during the course of acute inflammation, omega-3 polyunsaturated fatty acid-derived anti-inflammatory mediators including resolvins and protectins are produced. This review presents recent advances in understanding the formation and action of these mediators, especially focusing on the LC-MS/MS-based lipidomics approach and recently identified bioactive products with potent anti-inflammatory property.",
keywords = "Anti-inflammation, Lipid mediator, Metabolomics, Omega-3 fatty acid",
author = "Yosuke Isobe and Makoto Arita",
year = "2014",
doi = "10.3164/jcbn.14-18",
language = "English",
volume = "55",
pages = "79--84",
journal = "Journal of Clinical Biochemistry and Nutrition",
issn = "0912-0009",
publisher = "The Society for Free Radical Research Japan",
number = "2",

}

TY - JOUR

T1 - Identification of novel omega-3 fatty acid-derived bioactive metabolites based on a targeted lipidomics approach

AU - Isobe, Yosuke

AU - Arita, Makoto

PY - 2014

Y1 - 2014

N2 - Omega-3 Polyunsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid have beneficial effects in many inflammatory disorders. Although the mechanism of eicosapentaenoic acid and docosahexaenoic acid action is still not fully defined in molecular terms, recent studies have revealed that, during the course of acute inflammation, omega-3 polyunsaturated fatty acid-derived anti-inflammatory mediators including resolvins and protectins are produced. This review presents recent advances in understanding the formation and action of these mediators, especially focusing on the LC-MS/MS-based lipidomics approach and recently identified bioactive products with potent anti-inflammatory property.

AB - Omega-3 Polyunsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid have beneficial effects in many inflammatory disorders. Although the mechanism of eicosapentaenoic acid and docosahexaenoic acid action is still not fully defined in molecular terms, recent studies have revealed that, during the course of acute inflammation, omega-3 polyunsaturated fatty acid-derived anti-inflammatory mediators including resolvins and protectins are produced. This review presents recent advances in understanding the formation and action of these mediators, especially focusing on the LC-MS/MS-based lipidomics approach and recently identified bioactive products with potent anti-inflammatory property.

KW - Anti-inflammation

KW - Lipid mediator

KW - Metabolomics

KW - Omega-3 fatty acid

UR - http://www.scopus.com/inward/record.url?scp=84908506234&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84908506234&partnerID=8YFLogxK

U2 - 10.3164/jcbn.14-18

DO - 10.3164/jcbn.14-18

M3 - Review article

AN - SCOPUS:84908506234

VL - 55

SP - 79

EP - 84

JO - Journal of Clinical Biochemistry and Nutrition

JF - Journal of Clinical Biochemistry and Nutrition

SN - 0912-0009

IS - 2

ER -