Identification of novel omega-3 fatty acid-derived bioactive metabolites based on a targeted lipidomics approach

Yosuke Isobe, Makoto Arita

Research output: Contribution to journalReview articlepeer-review

16 Citations (Scopus)

Abstract

Omega-3 Polyunsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid have beneficial effects in many inflammatory disorders. Although the mechanism of eicosapentaenoic acid and docosahexaenoic acid action is still not fully defined in molecular terms, recent studies have revealed that, during the course of acute inflammation, omega-3 polyunsaturated fatty acid-derived anti-inflammatory mediators including resolvins and protectins are produced. This review presents recent advances in understanding the formation and action of these mediators, especially focusing on the LC-MS/MS-based lipidomics approach and recently identified bioactive products with potent anti-inflammatory property.

Original languageEnglish
Pages (from-to)79-84
Number of pages6
JournalJournal of Clinical Biochemistry and Nutrition
Volume55
Issue number2
DOIs
Publication statusPublished - 2014
Externally publishedYes

Keywords

  • Anti-inflammation
  • Lipid mediator
  • Metabolomics
  • Omega-3 fatty acid

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Clinical Biochemistry

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