Identification of oligosaccharide-recognition molecules by phage-display technology

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Glycoconjugate-binding molecules can contribute a great deal to carbohydrate research and carbohydrate-related diseases. However, it is difficult to obtain carbohydrate-specific antibodies due to low immunogenicity of glycoconjugates. Recent phage-display technology serves a new methodology to identify glycoconjugate-specific molecules effectively from large repertory of candidates. Many libraries such as peptide library, antibody library, and mutation lectin library have been applied for this purpose. By using this system, we will be able to design carbohydrate-binding molecules having the affinity and specificity we need.

Original languageEnglish
Pages (from-to)133-145
Number of pages13
JournalTrends in Glycoscience and Glycotechnology
Volume19
Issue number107
DOIs
Publication statusPublished - 2007 May

Fingerprint

Bacteriophages
Oligosaccharides
Glycoconjugates
Display devices
Carbohydrates
Technology
Molecules
Peptide Library
Antibodies
Lectins
Libraries
Mutation
Research

Keywords

  • Affinity selection
  • Evolution
  • Glycoconjugates
  • Phage display
  • Random library

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

Cite this

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