Identification of oligosaccharide-recognition molecules by phage-display technology

Research output: Contribution to journalShort survey

1 Citation (Scopus)

Abstract

Glycoconjugate-binding molecules can contribute a great deal to carbohydrate research and carbohydrate-related diseases. However, it is difficult to obtain carbohydrate-specific antibodies due to low immunogenicity of glycoconjugates. Recent phage-display technology serves a new methodology to identify glycoconjugate-specific molecules effectively from large repertory of candidates. Many libraries such as peptide library, antibody library, and mutation lectin library have been applied for this purpose. By using this system, we will be able to design carbohydrate-binding molecules having the affinity and specificity we need.

Original languageEnglish
Pages (from-to)133-145
Number of pages13
JournalTrends in Glycoscience and Glycotechnology
Volume19
Issue number107
DOIs
Publication statusPublished - 2007 May 1

Keywords

  • Affinity selection
  • Evolution
  • Glycoconjugates
  • Phage display
  • Random library

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Identification of oligosaccharide-recognition molecules by phage-display technology'. Together they form a unique fingerprint.

  • Cite this