Abstract
Purpose The immunophenotypes of cancer stromal cells have been recognized as prognostic factors of cancer. The purpose of this study was to analyze the prognostic markers of high-grade neuroendocrine carcinomas of the lung (HGNEC; both small cell carcinoma and large cell neuroendocrine carcinoma) by examining the immunophenotypes of cancer stromal cells. Materials and methods One hundred and fifteen patients who underwent a complete resection of HGNEC were included in this study. We examined the presence of CD204-positive tumor-associated macrophages (TAMs), Foxp3-positive regulatory T cells (Tregs), and podoplaninpositive cancer-associated fibroblasts (CAFs) to evaluate the prognostic values of these markers. Results The number of CD204-positive TAMs and Foxp3-positive Tregs did not influence the overall survival (OS) or the relapse-free survival (RFS) of the patients. However, patients with podoplanin-positive CAFs had a significantly better prognosis than those with podoplaninnegative CAFs [OS: p = 0.002, RFS: p = 0.002, 5-year overall survival (5YR): 74 vs. 45 %]. According to subgroup analyses, patients with podoplanin-positive CAFs displayed a better prognosis for both small cell carcinoma (OS: p = 0.046, 5YR: 74 vs. 46 %) and large cell neuroendocrine carcinoma (OS: p = 0.020, 5YR: 74 vs. 45 %). Moreover, in multivariate analyses, the podoplanin status of the CAFs was shown to be a statistically significant independent predictor of recurrence. Conclusion The presence of podoplanin-positive CAFs had a favorable prognostic value, suggesting that the evaluation of podoplanin expression by CAFs would lead to a novel risk classification of patients.
| Original language | English |
|---|---|
| Pages (from-to) | 1869-1878 |
| Number of pages | 10 |
| Journal | Journal of Cancer Research and Clinical Oncology |
| Volume | 139 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2013 |
| Externally published | Yes |
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Keywords
- Cancer-associated fibroblasts
- High-grade neuroendocrine carcinomas
- Large cell neuroendocrine carcinoma
- Regulatory T cells
- Small cell carcinoma
- Tumor-associated macrophages
ASJC Scopus subject areas
- Cancer Research
- Oncology
- Medicine(all)
Cite this
Identification of prognostic immunophenotypic features in cancer stromal cells of high-grade neuroendocrine carcinomas of the lung. / Takahashi, Akiko; Ishii, Genichiro; Kinoshita, Tomonari; Yoshida, Tatsuya; Umemura, Shigeki; Hishida, Tomoyuki; Yoh, Kiyotaka; Niho, Seiji; Goto, Koichi; Ohmatsu, Hironobu; Ohe, Yuichiro; Nagai, Kanji; Ochiai, Atsushi.
In: Journal of Cancer Research and Clinical Oncology, Vol. 139, No. 11, 2013, p. 1869-1878.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Identification of prognostic immunophenotypic features in cancer stromal cells of high-grade neuroendocrine carcinomas of the lung
AU - Takahashi, Akiko
AU - Ishii, Genichiro
AU - Kinoshita, Tomonari
AU - Yoshida, Tatsuya
AU - Umemura, Shigeki
AU - Hishida, Tomoyuki
AU - Yoh, Kiyotaka
AU - Niho, Seiji
AU - Goto, Koichi
AU - Ohmatsu, Hironobu
AU - Ohe, Yuichiro
AU - Nagai, Kanji
AU - Ochiai, Atsushi
PY - 2013
Y1 - 2013
N2 - Purpose The immunophenotypes of cancer stromal cells have been recognized as prognostic factors of cancer. The purpose of this study was to analyze the prognostic markers of high-grade neuroendocrine carcinomas of the lung (HGNEC; both small cell carcinoma and large cell neuroendocrine carcinoma) by examining the immunophenotypes of cancer stromal cells. Materials and methods One hundred and fifteen patients who underwent a complete resection of HGNEC were included in this study. We examined the presence of CD204-positive tumor-associated macrophages (TAMs), Foxp3-positive regulatory T cells (Tregs), and podoplaninpositive cancer-associated fibroblasts (CAFs) to evaluate the prognostic values of these markers. Results The number of CD204-positive TAMs and Foxp3-positive Tregs did not influence the overall survival (OS) or the relapse-free survival (RFS) of the patients. However, patients with podoplanin-positive CAFs had a significantly better prognosis than those with podoplaninnegative CAFs [OS: p = 0.002, RFS: p = 0.002, 5-year overall survival (5YR): 74 vs. 45 %]. According to subgroup analyses, patients with podoplanin-positive CAFs displayed a better prognosis for both small cell carcinoma (OS: p = 0.046, 5YR: 74 vs. 46 %) and large cell neuroendocrine carcinoma (OS: p = 0.020, 5YR: 74 vs. 45 %). Moreover, in multivariate analyses, the podoplanin status of the CAFs was shown to be a statistically significant independent predictor of recurrence. Conclusion The presence of podoplanin-positive CAFs had a favorable prognostic value, suggesting that the evaluation of podoplanin expression by CAFs would lead to a novel risk classification of patients.
AB - Purpose The immunophenotypes of cancer stromal cells have been recognized as prognostic factors of cancer. The purpose of this study was to analyze the prognostic markers of high-grade neuroendocrine carcinomas of the lung (HGNEC; both small cell carcinoma and large cell neuroendocrine carcinoma) by examining the immunophenotypes of cancer stromal cells. Materials and methods One hundred and fifteen patients who underwent a complete resection of HGNEC were included in this study. We examined the presence of CD204-positive tumor-associated macrophages (TAMs), Foxp3-positive regulatory T cells (Tregs), and podoplaninpositive cancer-associated fibroblasts (CAFs) to evaluate the prognostic values of these markers. Results The number of CD204-positive TAMs and Foxp3-positive Tregs did not influence the overall survival (OS) or the relapse-free survival (RFS) of the patients. However, patients with podoplanin-positive CAFs had a significantly better prognosis than those with podoplaninnegative CAFs [OS: p = 0.002, RFS: p = 0.002, 5-year overall survival (5YR): 74 vs. 45 %]. According to subgroup analyses, patients with podoplanin-positive CAFs displayed a better prognosis for both small cell carcinoma (OS: p = 0.046, 5YR: 74 vs. 46 %) and large cell neuroendocrine carcinoma (OS: p = 0.020, 5YR: 74 vs. 45 %). Moreover, in multivariate analyses, the podoplanin status of the CAFs was shown to be a statistically significant independent predictor of recurrence. Conclusion The presence of podoplanin-positive CAFs had a favorable prognostic value, suggesting that the evaluation of podoplanin expression by CAFs would lead to a novel risk classification of patients.
KW - Cancer-associated fibroblasts
KW - High-grade neuroendocrine carcinomas
KW - Large cell neuroendocrine carcinoma
KW - Regulatory T cells
KW - Small cell carcinoma
KW - Tumor-associated macrophages
UR - http://www.scopus.com/inward/record.url?scp=84892668814&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84892668814&partnerID=8YFLogxK
U2 - 10.1007/s00432-013-1502-5
DO - 10.1007/s00432-013-1502-5
M3 - Article
C2 - 24013219
AN - SCOPUS:84892668814
VL - 139
SP - 1869
EP - 1878
JO - Journal of Cancer Research and Clinical Oncology
JF - Journal of Cancer Research and Clinical Oncology
SN - 0171-5216
IS - 11
ER -