Identification of the toxic trigger in mushroom poisoning

Masanori Matsuura, Yoko Saikawa, Kosei Inui, Koichi Nakae, Masayuki Igarashi, Kimiko Hashimoto, Masaya Nakata

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

We have isolated the small, highly strained carboxylic acid cycloprop-2-ene carboxylic acid from the Asian toxic mushroom Russula subnigricans. This compound is responsible for fatal rhabdomyolysis, a new type of mushroom poisoning that is indicated by an increase in serum creatine phosphokinase activity in mice. We found that polymerization of the compound at high concentrations via ene reaction abolishes its toxicity.

Original languageEnglish
Pages (from-to)465-467
Number of pages3
JournalNature Chemical Biology
Volume5
Issue number7
DOIs
Publication statusPublished - 2009 Jul

Fingerprint

Mushroom Poisoning
Rhabdomyolysis
Poisons
Agaricales
Creatine Kinase
Carboxylic Acids
Polymerization
Serum
cycloprop-2-ene carboxylic acid

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Matsuura, M., Saikawa, Y., Inui, K., Nakae, K., Igarashi, M., Hashimoto, K., & Nakata, M. (2009). Identification of the toxic trigger in mushroom poisoning. Nature Chemical Biology, 5(7), 465-467. https://doi.org/10.1038/nchembio.179

Identification of the toxic trigger in mushroom poisoning. / Matsuura, Masanori; Saikawa, Yoko; Inui, Kosei; Nakae, Koichi; Igarashi, Masayuki; Hashimoto, Kimiko; Nakata, Masaya.

In: Nature Chemical Biology, Vol. 5, No. 7, 07.2009, p. 465-467.

Research output: Contribution to journalArticle

Matsuura, M, Saikawa, Y, Inui, K, Nakae, K, Igarashi, M, Hashimoto, K & Nakata, M 2009, 'Identification of the toxic trigger in mushroom poisoning', Nature Chemical Biology, vol. 5, no. 7, pp. 465-467. https://doi.org/10.1038/nchembio.179
Matsuura M, Saikawa Y, Inui K, Nakae K, Igarashi M, Hashimoto K et al. Identification of the toxic trigger in mushroom poisoning. Nature Chemical Biology. 2009 Jul;5(7):465-467. https://doi.org/10.1038/nchembio.179
Matsuura, Masanori ; Saikawa, Yoko ; Inui, Kosei ; Nakae, Koichi ; Igarashi, Masayuki ; Hashimoto, Kimiko ; Nakata, Masaya. / Identification of the toxic trigger in mushroom poisoning. In: Nature Chemical Biology. 2009 ; Vol. 5, No. 7. pp. 465-467.
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