Identification of the toxic trigger in mushroom poisoning

Masanori Matsuura, Yoko Saikawa, Kosei Inui, Koichi Nakae, Masayuki Igarashi, Kimiko Hashimoto, Masaya Nakata

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)

Abstract

We have isolated the small, highly strained carboxylic acid cycloprop-2-ene carboxylic acid from the Asian toxic mushroom Russula subnigricans. This compound is responsible for fatal rhabdomyolysis, a new type of mushroom poisoning that is indicated by an increase in serum creatine phosphokinase activity in mice. We found that polymerization of the compound at high concentrations via ene reaction abolishes its toxicity.

Original languageEnglish
Pages (from-to)465-467
Number of pages3
JournalNature Chemical Biology
Volume5
Issue number7
DOIs
Publication statusPublished - 2009 Jul

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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