Identification of tumor antigens recognized by T cells and their use for analysis of anti-tumor responses

Tomonobu Fujita, Yutaka Kawakami

Research output: Contribution to journalArticle

Abstract

One of the problems in the development of immunotherapy in the past was poor evaluation of anti-tumor immune responses. Consequently, it was difficult to improve the immunotherapy. Various human tumor antigens recognized by T cells have recently been identified using various methods, including cDNA expression cloning with tumor reactive T cells and antibodies, as well as various cDNA subtraction methods in combination with in vitro T cell induction. The identification of tumor antigenic peptides recognized by T cells allows us to monitor anti-tumor T cell response quantitatively and qualitatively during immunotherapy as well as to develop more efficient immunotherapy with a sufficient amount of antigens in more immunogenic forms.

Original languageEnglish
Pages (from-to)441-448
Number of pages8
JournalBiotherapy
Volume16
Issue number5
Publication statusPublished - 2002 Sep 1

Keywords

  • CDNA expression cloning
  • HLA tetramer
  • Immunotherapy
  • T cell
  • Tumor antigens

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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