Identification of two new HLA-A*1101-restricted tax epitopes recognized by cytotoxic T lymphocytes in an adult T-cell leukemia patient after hematopoietic stem cell transplantation

Nanae Harashima, Ryuji Tanosaki, Yukiko Shimizu, Kiyoshi Kurihara, Takao Masuda, Jun Okamura, Mari Kannagi

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We previously reported that Tax-specific CD8 + cytotoxic T lymphocytes (CTLs), directed to single epitopes restricted by HLA-A2 or A24, expanded in vitro and in vivo in peripheral blood mononuclear cells (PBMC) from some adult T-cell leukemia (ATL) patients after but not before allogeneic hematopoietic stem cell transplantation (HSCT). Here, we demonstrated similar Tax-specific CTL expansion in PBMC from another post-HSCT ATL patient without HLA-A2 or A24, whose CTLs equally recognized two newly identified epitopes, Tax88-96 and Tax272-280, restricted by HLA-A11, suggesting that these immunodominant Tax epitopes are present in the ATL patient in vivo.

Original languageEnglish
Pages (from-to)10088-10092
Number of pages5
JournalJournal of Virology
Volume79
Issue number15
DOIs
Publication statusPublished - 2005 Aug
Externally publishedYes

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Adult T Cell Leukemia Lymphoma
cell transplantation
cytotoxic T-lymphocytes
HLA-A Antigens
Hematopoietic Stem Cell Transplantation
Cytotoxic T-Lymphocytes
taxes
HLA-A24 Antigen
leukemia
epitopes
HLA-A2 Antigen
Epitopes
T-lymphocytes
mononuclear leukocytes
Blood Cells
HLA-A11 Antigen
Immunodominant Epitopes
hematopoietic stem cells

ASJC Scopus subject areas

  • Immunology

Cite this

Identification of two new HLA-A*1101-restricted tax epitopes recognized by cytotoxic T lymphocytes in an adult T-cell leukemia patient after hematopoietic stem cell transplantation. / Harashima, Nanae; Tanosaki, Ryuji; Shimizu, Yukiko; Kurihara, Kiyoshi; Masuda, Takao; Okamura, Jun; Kannagi, Mari.

In: Journal of Virology, Vol. 79, No. 15, 08.2005, p. 10088-10092.

Research output: Contribution to journalArticle

Harashima, Nanae ; Tanosaki, Ryuji ; Shimizu, Yukiko ; Kurihara, Kiyoshi ; Masuda, Takao ; Okamura, Jun ; Kannagi, Mari. / Identification of two new HLA-A*1101-restricted tax epitopes recognized by cytotoxic T lymphocytes in an adult T-cell leukemia patient after hematopoietic stem cell transplantation. In: Journal of Virology. 2005 ; Vol. 79, No. 15. pp. 10088-10092.
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