IgA plasma cells express the negative regulatory co-stimulatory molecule programmed cell death 1 ligand and have a potential tolerogenic role in the intestine

Tomomitsu Doi, Takanori Kanai, Yohei Mikami, Tomohisa Sujino, Li Jun, Yuichi Ono, Atsushi Hayashi, Toshifumi Hibi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

To maintain immune homeostasis in the intestine, the intestinal immune system has evolved several tolerogenic mechanisms toward intestinal microflora and food antigens. Although programmed cell death-1 (PD-1) protein has been implicated in immunological tolerance in the intestine and gut-associated lymphoid tissues (GALTs), distribution of its ligands PD-L1 and PD-L2 in the small intestine lamina propria (LP) are unknown. We investigated PD-L1 expression in intestinal LP and found that IgA plasma cells (PCs) were major PD-L1 expressing cells. PD-L1 expression levels on IgA PCs were higher than that on IgG PCs in peripheral lymphoid tissues. IgA PCs expressed antigen-presenting molecule MHC class II and co-stimulatory molecules CD80, CD86, and PD-L2. IgA PCs isolated from intestinal LP exhibited antigen presentation activity, and in the presence of TGF-β induced FoxP3+ regulatory T cells, but not IFN-γ+ Th1 cells, from naïve T cells. Thus, IgA PCs in the intestine may be involved in an immune regulatory role in the intestinal immune system.

Original languageEnglish
Pages (from-to)918-923
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume425
Issue number4
DOIs
Publication statusPublished - 2012 Sep 7

Fingerprint

Cell death
Plasma Cells
Immunoglobulin A
Intestines
Cell Death
Ligands
Plasmas
Molecules
Mucous Membrane
T-cells
Immune system
Lymphoid Tissue
Programmed Cell Death 1 Receptor
Immune System
Tissue
Antigens
Th1 Cells
Antigen Presentation
Regulatory T-Lymphocytes
Tissue Distribution

Keywords

  • FoxP3
  • Intestine
  • PD-L1
  • Plasma cells
  • Tolerance

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

Cite this

IgA plasma cells express the negative regulatory co-stimulatory molecule programmed cell death 1 ligand and have a potential tolerogenic role in the intestine. / Doi, Tomomitsu; Kanai, Takanori; Mikami, Yohei; Sujino, Tomohisa; Jun, Li; Ono, Yuichi; Hayashi, Atsushi; Hibi, Toshifumi.

In: Biochemical and Biophysical Research Communications, Vol. 425, No. 4, 07.09.2012, p. 918-923.

Research output: Contribution to journalArticle

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AU - Jun, Li

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AU - Hayashi, Atsushi

AU - Hibi, Toshifumi

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