Ikoamide, an Antimalarial Lipopeptide from an Okeania sp. Marine Cyanobacterium

Keitaro Iwasaki, Arihiro Iwasaki, Shimpei Sumimoto, Teruhiko Matsubara, Toshinori Sato, Tomoyoshi Nozaki, Yumiko Saito-Nakano, Kiyotake Suenaga

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

An antimalarial lipopeptide, ikoamide, was isolated from an Okeania sp. marine cyanobacterium. Its gross structure was established by spectroscopic analyses, and the absolute configuration was clarified based on a combination of chiral-phase HPLC analyses, spectroscopic analyses, and derivatization reactions. Ikoamide showed strong antimalarial activity with an IC50 value of 0.14 μM without cytotoxicity against human cancer cell lines at 10 μM.

Original languageEnglish
Pages (from-to)481-488
Number of pages8
JournalJournal of Natural Products
Volume83
Issue number2
DOIs
Publication statusPublished - 2020 Feb 28

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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