IL-6 and G-CSF production resulting from lung cancer in an HIV patient

Naoki Kawakami, Ho Namkoong, Katsunori Masaki, Yutaka Kurebayashi, Masayuki Shimoda, Hiroshi Kotani, Hiroshi Fujiwara, Naoki Hasegawa

Research output: Contribution to journalArticle

Abstract

Increasing reports have noted an increased prevalence of lung cancer in human immunodeficiency virus (HIV)-positive patients with poor prognosis. A 51-year-old HIV-positive man was diagnosed with stage IV squamous cell lung cancer. He had high grade spike intermittent fever and persistent elevation of the white blood cell count as well as C-reactive protein (CRP) levels. Although we suspected opportunistic infections, we did not detect any infection. The autopsy showed positive immunostaining for Interleukin-6 (IL-6) in plasma cells of the stromal regions and G-CSF in tumor cells, which were considered responsible for his significant tumor fever, leukocytosis and high titers of CRP. This case report highlights the need to consider cytokine-producing tumor as a differential diagnosis of fever and high inflammatory status in HIV-positive cancer patients.

Original languageEnglish
Article numbere00693
JournalIDCases
Volume19
DOIs
Publication statusPublished - 2020

Fingerprint

Granulocyte Colony-Stimulating Factor
Interleukin-6
Lung Neoplasms
HIV
Fever
C-Reactive Protein
Neoplasms
Squamous Cell Neoplasms
Leukocytosis
Opportunistic Infections
Plasma Cells
Leukocyte Count
Autopsy
Differential Diagnosis
Cytokines
Infection

Keywords

  • G-CSF
  • Human immunodeficiency virus (HIV)
  • IL-6
  • Lung cancer
  • Tumor fever

ASJC Scopus subject areas

  • Infectious Diseases

Cite this

IL-6 and G-CSF production resulting from lung cancer in an HIV patient. / Kawakami, Naoki; Namkoong, Ho; Masaki, Katsunori; Kurebayashi, Yutaka; Shimoda, Masayuki; Kotani, Hiroshi; Fujiwara, Hiroshi; Hasegawa, Naoki.

In: IDCases, Vol. 19, e00693, 2020.

Research output: Contribution to journalArticle

Kawakami, N, Namkoong, H, Masaki, K, Kurebayashi, Y, Shimoda, M, Kotani, H, Fujiwara, H & Hasegawa, N 2020, 'IL-6 and G-CSF production resulting from lung cancer in an HIV patient', IDCases, vol. 19, e00693. https://doi.org/10.1016/j.idcr.2020.e00693
Kawakami N, Namkoong H, Masaki K, Kurebayashi Y, Shimoda M, Kotani H et al. IL-6 and G-CSF production resulting from lung cancer in an HIV patient. IDCases. 2020;19. e00693. https://doi.org/10.1016/j.idcr.2020.e00693
Kawakami, Naoki ; Namkoong, Ho ; Masaki, Katsunori ; Kurebayashi, Yutaka ; Shimoda, Masayuki ; Kotani, Hiroshi ; Fujiwara, Hiroshi ; Hasegawa, Naoki. / IL-6 and G-CSF production resulting from lung cancer in an HIV patient. In: IDCases. 2020 ; Vol. 19.
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AU - Kotani, Hiroshi

AU - Fujiwara, Hiroshi

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