IL-6 and related cytokines as the critical lynchpins between inflammation and cancer

Koji Taniguchi, Michael Karin

Research output: Contribution to journalReview article

289 Citations (Scopus)

Abstract

Inflammatory responses play pivotal roles in cancer development, including tumor initiation, promotion, progression, and metastasis. Cytokines are now recognized as important mediators linking inflammation and cancer, and are therefore potential therapeutic and preventive targets as well as prognostic factors. The interleukin (IL)-6 family of cytokines, especially IL-6 and IL-11, is highly up-regulated in many cancers and considered as one of the most important cytokine families during tumorigenesis and metastasis. This review discusses molecular mechanisms linking the IL-6 cytokine family to solid malignancies and their treatment.

Original languageEnglish
Pages (from-to)54-74
Number of pages21
JournalSeminars in Immunology
Volume26
Issue number1
DOIs
Publication statusPublished - 2014 Feb

Keywords

  • Colorectal cancer
  • Gastric cancer
  • Gp130
  • Hepatocellular carcinoma
  • IL-11
  • IL-6
  • STAT3

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'IL-6 and related cytokines as the critical lynchpins between inflammation and cancer'. Together they form a unique fingerprint.

  • Cite this