ILCs and Allergy

Hiroki Kabata, Yasutaka Motomura, Tsuyoshi Kiniwa, Tetsuro Kobayashi, Kazuyo Moro

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The recent discovery of new innate lymphoid cells (ILCs) has revolutionized the field of allergies. Since most allergic diseases induce a type 2 immune response, Th2 cells, which produce IL-4, IL-5, and IL-13 in an antigen-dependent manner, in addition to basophils and mast cells which are activated by antigen-specific IgE, are thought to play a major role in the pathogenesis. However, since group 2 innate lymphoid cells (ILC2s) produce type 2 cytokines (i.e., IL-2, IL-4, IL-5, IL-6, IL-9, IL-13, GM-CSF, and amphiregulin) in response to various cytokines, including IL-33 in the surrounding environment, the possibility has emerged that there are two types of allergies: allergies induced in an antigen-dependent manner by Th2 cells and allergies induced in an antigen-independent manner by ILC2s. In order to make an impact on the increasing incidence of allergic diseases in the world, it is essential to research and develop new treatments that focus not only on Th2 cells but also on ILC2s. In this chapter, the role of ILCs in allergic diseases, which has rapidly changed with the discovery of ILCs, is discussed, focusing mainly on ILC2s.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer
Pages75-95
Number of pages21
DOIs
Publication statusPublished - 2022

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1365
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Allergic conjunctivitis
  • Allergic rhinitis
  • Asthma
  • Atopic dermatitis
  • Chronic rhinosinusitis
  • Contact hypersensitivity
  • Food allergy

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint

Dive into the research topics of 'ILCs and Allergy'. Together they form a unique fingerprint.

Cite this