Imaging correlates of molecular signatures in oligodendrogliomas

Joseph F. Megyesi, Edward Kachur, Donald H. Lee, Magdalena C. Zlatescu, Rebecca A. Betensky, Peter A. Forsyth, Yoshifumi Okada, Hikaru Sasaki, Masahiro Mizoguchi, David N. Louis, J. Gregory Cairncross

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

Molecular subsets of oligodendroglioma behave in biologically distinct ways. Their locations in the brain, rates of growth, and responses to therapy differ with their genotypes. Retrospectively, we inquired whether allelic loss of chromosomal arms 1p and 19q, an early molecular event and favorable prognostic marker in oligodendrogliomas, were reflected in their appearance on magnetic resonance imaging. Loss of 1p and 19q was associated with an indistinct border on T1 images and mixed intensity signal on T1 and T2. Loss of 1p and 19q was also associated with paramagnetic susceptibility effect and with calcification, a common histopathological finding in oligodendrogliomas. These data encourage prospective evaluation of molecular alterations and magnetic resonance imaging characteristics of glial neoplasms.

Original languageEnglish
Pages (from-to)4303-4306
Number of pages4
JournalClinical Cancer Research
Volume10
Issue number13
DOIs
Publication statusPublished - 2004 Jul 1
Externally publishedYes

Fingerprint

Oligodendroglioma
Molecular Imaging
Magnetic Resonance Imaging
Loss of Heterozygosity
Neuroglia
Genotype
Brain
Growth
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Megyesi, J. F., Kachur, E., Lee, D. H., Zlatescu, M. C., Betensky, R. A., Forsyth, P. A., ... Cairncross, J. G. (2004). Imaging correlates of molecular signatures in oligodendrogliomas. Clinical Cancer Research, 10(13), 4303-4306. https://doi.org/10.1158/1078-0432.CCR-04-0209

Imaging correlates of molecular signatures in oligodendrogliomas. / Megyesi, Joseph F.; Kachur, Edward; Lee, Donald H.; Zlatescu, Magdalena C.; Betensky, Rebecca A.; Forsyth, Peter A.; Okada, Yoshifumi; Sasaki, Hikaru; Mizoguchi, Masahiro; Louis, David N.; Cairncross, J. Gregory.

In: Clinical Cancer Research, Vol. 10, No. 13, 01.07.2004, p. 4303-4306.

Research output: Contribution to journalArticle

Megyesi, JF, Kachur, E, Lee, DH, Zlatescu, MC, Betensky, RA, Forsyth, PA, Okada, Y, Sasaki, H, Mizoguchi, M, Louis, DN & Cairncross, JG 2004, 'Imaging correlates of molecular signatures in oligodendrogliomas', Clinical Cancer Research, vol. 10, no. 13, pp. 4303-4306. https://doi.org/10.1158/1078-0432.CCR-04-0209
Megyesi JF, Kachur E, Lee DH, Zlatescu MC, Betensky RA, Forsyth PA et al. Imaging correlates of molecular signatures in oligodendrogliomas. Clinical Cancer Research. 2004 Jul 1;10(13):4303-4306. https://doi.org/10.1158/1078-0432.CCR-04-0209
Megyesi, Joseph F. ; Kachur, Edward ; Lee, Donald H. ; Zlatescu, Magdalena C. ; Betensky, Rebecca A. ; Forsyth, Peter A. ; Okada, Yoshifumi ; Sasaki, Hikaru ; Mizoguchi, Masahiro ; Louis, David N. ; Cairncross, J. Gregory. / Imaging correlates of molecular signatures in oligodendrogliomas. In: Clinical Cancer Research. 2004 ; Vol. 10, No. 13. pp. 4303-4306.
@article{cfe4f94f81164f729a09effbcebb4439,
title = "Imaging correlates of molecular signatures in oligodendrogliomas",
abstract = "Molecular subsets of oligodendroglioma behave in biologically distinct ways. Their locations in the brain, rates of growth, and responses to therapy differ with their genotypes. Retrospectively, we inquired whether allelic loss of chromosomal arms 1p and 19q, an early molecular event and favorable prognostic marker in oligodendrogliomas, were reflected in their appearance on magnetic resonance imaging. Loss of 1p and 19q was associated with an indistinct border on T1 images and mixed intensity signal on T1 and T2. Loss of 1p and 19q was also associated with paramagnetic susceptibility effect and with calcification, a common histopathological finding in oligodendrogliomas. These data encourage prospective evaluation of molecular alterations and magnetic resonance imaging characteristics of glial neoplasms.",
author = "Megyesi, {Joseph F.} and Edward Kachur and Lee, {Donald H.} and Zlatescu, {Magdalena C.} and Betensky, {Rebecca A.} and Forsyth, {Peter A.} and Yoshifumi Okada and Hikaru Sasaki and Masahiro Mizoguchi and Louis, {David N.} and Cairncross, {J. Gregory}",
year = "2004",
month = "7",
day = "1",
doi = "10.1158/1078-0432.CCR-04-0209",
language = "English",
volume = "10",
pages = "4303--4306",
journal = "Clinical Cancer Research",
issn = "1078-0432",
publisher = "American Association for Cancer Research Inc.",
number = "13",

}

TY - JOUR

T1 - Imaging correlates of molecular signatures in oligodendrogliomas

AU - Megyesi, Joseph F.

AU - Kachur, Edward

AU - Lee, Donald H.

AU - Zlatescu, Magdalena C.

AU - Betensky, Rebecca A.

AU - Forsyth, Peter A.

AU - Okada, Yoshifumi

AU - Sasaki, Hikaru

AU - Mizoguchi, Masahiro

AU - Louis, David N.

AU - Cairncross, J. Gregory

PY - 2004/7/1

Y1 - 2004/7/1

N2 - Molecular subsets of oligodendroglioma behave in biologically distinct ways. Their locations in the brain, rates of growth, and responses to therapy differ with their genotypes. Retrospectively, we inquired whether allelic loss of chromosomal arms 1p and 19q, an early molecular event and favorable prognostic marker in oligodendrogliomas, were reflected in their appearance on magnetic resonance imaging. Loss of 1p and 19q was associated with an indistinct border on T1 images and mixed intensity signal on T1 and T2. Loss of 1p and 19q was also associated with paramagnetic susceptibility effect and with calcification, a common histopathological finding in oligodendrogliomas. These data encourage prospective evaluation of molecular alterations and magnetic resonance imaging characteristics of glial neoplasms.

AB - Molecular subsets of oligodendroglioma behave in biologically distinct ways. Their locations in the brain, rates of growth, and responses to therapy differ with their genotypes. Retrospectively, we inquired whether allelic loss of chromosomal arms 1p and 19q, an early molecular event and favorable prognostic marker in oligodendrogliomas, were reflected in their appearance on magnetic resonance imaging. Loss of 1p and 19q was associated with an indistinct border on T1 images and mixed intensity signal on T1 and T2. Loss of 1p and 19q was also associated with paramagnetic susceptibility effect and with calcification, a common histopathological finding in oligodendrogliomas. These data encourage prospective evaluation of molecular alterations and magnetic resonance imaging characteristics of glial neoplasms.

UR - http://www.scopus.com/inward/record.url?scp=3042851659&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3042851659&partnerID=8YFLogxK

U2 - 10.1158/1078-0432.CCR-04-0209

DO - 10.1158/1078-0432.CCR-04-0209

M3 - Article

VL - 10

SP - 4303

EP - 4306

JO - Clinical Cancer Research

JF - Clinical Cancer Research

SN - 1078-0432

IS - 13

ER -