Imaging correlates of molecular signatures in oligodendrogliomas

Joseph F. Megyesi, Edward Kachur, Donald H. Lee, Magdalena C. Zlatescu, Rebecca A. Betensky, Peter A. Forsyth, Yoshifumi Okada, Hikaru Sasaki, Masahiro Mizoguchi, David N. Louis, J. Gregory Cairncross

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Abstract

Molecular subsets of oligodendroglioma behave in biologically distinct ways. Their locations in the brain, rates of growth, and responses to therapy differ with their genotypes. Retrospectively, we inquired whether allelic loss of chromosomal arms 1p and 19q, an early molecular event and favorable prognostic marker in oligodendrogliomas, were reflected in their appearance on magnetic resonance imaging. Loss of 1p and 19q was associated with an indistinct border on T1 images and mixed intensity signal on T1 and T2. Loss of 1p and 19q was also associated with paramagnetic susceptibility effect and with calcification, a common histopathological finding in oligodendrogliomas. These data encourage prospective evaluation of molecular alterations and magnetic resonance imaging characteristics of glial neoplasms.

Original languageEnglish
Pages (from-to)4303-4306
Number of pages4
JournalClinical Cancer Research
Volume10
Issue number13
DOIs
Publication statusPublished - 2004 Jul 1

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Megyesi, J. F., Kachur, E., Lee, D. H., Zlatescu, M. C., Betensky, R. A., Forsyth, P. A., Okada, Y., Sasaki, H., Mizoguchi, M., Louis, D. N., & Cairncross, J. G. (2004). Imaging correlates of molecular signatures in oligodendrogliomas. Clinical Cancer Research, 10(13), 4303-4306. https://doi.org/10.1158/1078-0432.CCR-04-0209