Imaging of flow pattern in micro flow channel using surface plasmon resonance

Yuzuru Iwasaki, Tatsuya Tobita, Kazuyoshi Kurihara, Tsutomu Horiuchi, Koji Suzuki, Osamu Niwa

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


We describe the visualization of the mixing and control of flow patterns in micro fluidic devices using a surface plasmon resonance (SPR) imaging sensor. We employed Kretschmann-type prism coupling SPR optics and an expanded laser diode light source via a single mode optical fibre. The reflected light was focused on a CCD camera. Two types of micro fluidic device were fabricated using photolithography and polymer imprinting a 2 mm wide, 100 νm high channel flow cell for the mixing and a slab channel device for flow control. We were able to observe mixing in the flow channel in real time with SPR imaging as the local refractive index change. Because the sensitivity of this system was limited within wavelength long distance from the gold surface, we could image the flow condition very near the channel wall. We also succeed in delivering the flow to a part of 4 × 4-array sensing area in a slab flow channel. These results will assist the development of integrated biosensors.

Original languageEnglish
Article numberS11
Pages (from-to)3184-3188
Number of pages5
JournalMeasurement Science and Technology
Issue number12
Publication statusPublished - 2006 Dec 1


  • Array
  • Confluence
  • Imaging
  • Micro channel
  • Mixing
  • Surface plasmon resonance

ASJC Scopus subject areas

  • Instrumentation
  • Engineering (miscellaneous)
  • Applied Mathematics


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