IMETHYL: An integrative database of human DNA methylation, gene expression, and genomic variation

Shohei Komaki, Yuh Shiwa, Ryohei Furukawa, Tsuyoshi Hachiya, Hideki Ohmomo, Ryo Otomo, Mamoru Satoh, Jiro Hitomi, Kenji Sobue, Makoto Sasaki, Atsushi Shimizu

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We launched an integrative multi-omics database, iMETHYL (http://imethyl.iwate-megabank.org). iMETHYL provides whole-DNA methylation (∼24 million autosomal CpG sites), whole-genome (∼9 million single-nucleotide variants), and whole-Transcriptome (>14 000 genes) data for CD4 + T-lymphocytes, monocytes, and neutrophils collected from approximately 100 subjects. These data were obtained from whole-genome bisulfite sequencing, whole-genome sequencing, and whole-Transcriptome sequencing, making iMETHYL a comprehensive database.

Original languageEnglish
Article number18008
JournalHuman Genome Variation
Volume5
DOIs
Publication statusPublished - 2018 Mar 29
Externally publishedYes

Fingerprint

DNA Methylation
Gene expression
Genes
Genome
Databases
Transcriptome
Gene Expression
T-cells
Monocytes
Neutrophils
Nucleotides
T-Lymphocytes

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Molecular Biology

Cite this

IMETHYL : An integrative database of human DNA methylation, gene expression, and genomic variation. / Komaki, Shohei; Shiwa, Yuh; Furukawa, Ryohei; Hachiya, Tsuyoshi; Ohmomo, Hideki; Otomo, Ryo; Satoh, Mamoru; Hitomi, Jiro; Sobue, Kenji; Sasaki, Makoto; Shimizu, Atsushi.

In: Human Genome Variation, Vol. 5, 18008, 29.03.2018.

Research output: Contribution to journalArticle

Komaki, S, Shiwa, Y, Furukawa, R, Hachiya, T, Ohmomo, H, Otomo, R, Satoh, M, Hitomi, J, Sobue, K, Sasaki, M & Shimizu, A 2018, 'IMETHYL: An integrative database of human DNA methylation, gene expression, and genomic variation', Human Genome Variation, vol. 5, 18008. https://doi.org/10.1038/hgv.2018.8
Komaki, Shohei ; Shiwa, Yuh ; Furukawa, Ryohei ; Hachiya, Tsuyoshi ; Ohmomo, Hideki ; Otomo, Ryo ; Satoh, Mamoru ; Hitomi, Jiro ; Sobue, Kenji ; Sasaki, Makoto ; Shimizu, Atsushi. / IMETHYL : An integrative database of human DNA methylation, gene expression, and genomic variation. In: Human Genome Variation. 2018 ; Vol. 5.
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