IMI – Clinical myopia control trials and instrumentation report

James S. Wolffsohn, Pete S. Kollbaum, David A. Berntsen, David A. Atchison, Alexandra Benavente, Arthur Bradley, Hetal Buckhurst, Michael Collins, Takashi Fujikado, Takahiro Hiraoka, Masakazu Hirota, Debbie Jones, Nicola S. Logan, Linda Lundström, Hidemasa Torii, Scott A. Read, Kovin Naidoo

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The evidence-basis based on existing myopia control trials along with the supporting academic literature were reviewed; this informed recommendations on the outcomes suggested from clinical trials aimed at slowing myopia progression to show the effectiveness of treatments and the impact on patients. These outcomes were classified as primary (refractive error and/or axial length), secondary (patient reported outcomes and treatment compliance), and exploratory (peripheral refraction, accommodative changes, ocular alignment, pupil size, outdoor activity/ lighting levels, anterior and posterior segment imaging, and tissue biomechanics). The currently available instrumentation, which the literature has shown to best achieve the primary and secondary outcomes, was reviewed and critiqued. Issues relating to study design and patient selection were also identified. These findings and consensus from the International Myopia Institute members led to final recommendations to inform future instrumentation development and to guide clinical trial protocols.

Original languageEnglish
Pages (from-to)M132-M160
JournalInvestigative Ophthalmology and Visual Science
Volume60
DOIs
Publication statusPublished - 2019 Feb 1

Fingerprint

Myopia
Clinical Protocols
Clinical Trials
Refractive Errors
Pupil
Lighting
Biomechanical Phenomena
Patient Selection
Therapeutics

Keywords

  • Clinical trial guidelines
  • Instrumentation
  • Myopia control
  • Myopia progression
  • Recommendations

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Wolffsohn, J. S., Kollbaum, P. S., Berntsen, D. A., Atchison, D. A., Benavente, A., Bradley, A., ... Naidoo, K. (2019). IMI – Clinical myopia control trials and instrumentation report. Investigative Ophthalmology and Visual Science, 60, M132-M160. https://doi.org/10.1167/iovs.18-25955

IMI – Clinical myopia control trials and instrumentation report. / Wolffsohn, James S.; Kollbaum, Pete S.; Berntsen, David A.; Atchison, David A.; Benavente, Alexandra; Bradley, Arthur; Buckhurst, Hetal; Collins, Michael; Fujikado, Takashi; Hiraoka, Takahiro; Hirota, Masakazu; Jones, Debbie; Logan, Nicola S.; Lundström, Linda; Torii, Hidemasa; Read, Scott A.; Naidoo, Kovin.

In: Investigative Ophthalmology and Visual Science, Vol. 60, 01.02.2019, p. M132-M160.

Research output: Contribution to journalArticle

Wolffsohn, JS, Kollbaum, PS, Berntsen, DA, Atchison, DA, Benavente, A, Bradley, A, Buckhurst, H, Collins, M, Fujikado, T, Hiraoka, T, Hirota, M, Jones, D, Logan, NS, Lundström, L, Torii, H, Read, SA & Naidoo, K 2019, 'IMI – Clinical myopia control trials and instrumentation report', Investigative Ophthalmology and Visual Science, vol. 60, pp. M132-M160. https://doi.org/10.1167/iovs.18-25955
Wolffsohn JS, Kollbaum PS, Berntsen DA, Atchison DA, Benavente A, Bradley A et al. IMI – Clinical myopia control trials and instrumentation report. Investigative Ophthalmology and Visual Science. 2019 Feb 1;60:M132-M160. https://doi.org/10.1167/iovs.18-25955
Wolffsohn, James S. ; Kollbaum, Pete S. ; Berntsen, David A. ; Atchison, David A. ; Benavente, Alexandra ; Bradley, Arthur ; Buckhurst, Hetal ; Collins, Michael ; Fujikado, Takashi ; Hiraoka, Takahiro ; Hirota, Masakazu ; Jones, Debbie ; Logan, Nicola S. ; Lundström, Linda ; Torii, Hidemasa ; Read, Scott A. ; Naidoo, Kovin. / IMI – Clinical myopia control trials and instrumentation report. In: Investigative Ophthalmology and Visual Science. 2019 ; Vol. 60. pp. M132-M160.
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