Immediate effects of active exercise with compression therapy on lower-limb lymphedema

Takuya Fukushima, Tetsuya Tsuji, Yufuko Sano, Chieko Miyata, Michiyo Kamisako, Hiroka Hohri, Chikako Yoshimura, Megumi Asakura, Taro Okitsu, Kaori Muraoka, Meigen Liu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Purpose: Active exercise with compression therapy (AECT) is a standard treatment for gynecological cancer-related lower-limb lymphedema (LLL) in clinical situations. However, there is insufficient evidence regarding the immediate effects of the use of AECT on LLL. The purpose of this study was to evaluate the immediate effects of AECT on LLL. Methods: Participants in this randomized controlled crossover trial comprised 23 women with LLL who completed high-load AECT, low-load AECT, and compression-only therapy (CT). AECT was performed on a bicycle ergometer with short stretch bandages. Each intervention was performed for 15 min, with successive interventions separated by a 1-week washout period. Lower-limb volume was assessed using a Perometer™ sensor (Pero-system, Wuppertal, Germany). General symptoms (pain and heaviness) and skin symptoms (pitting and stiffness) were assessed using a visual analog scale and palpation, respectively. Measurements were taken before and after each intervention. Analysis of variance using linear mixed-effect modeling was used for statistical analyses. Results: Volume decrement differed significantly between all three interventions (P < 0.05). Lower-limb volume was significantly reduced after high-load AECT compared to that after CT. General symptoms and skin symptoms were similar across the three interventions, but severity of pre-intervention skin symptoms correlated significantly with volume decrement after high- and low-load AECT. High-load AECT using the bicycle ergometer was more effective than CT for decreasing lower-limb volume. Conclusions: These results suggest that high-load AECT has marked effects on severe LLL.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalSupportive Care in Cancer
DOIs
Publication statusAccepted/In press - 2017 Apr 6

Fingerprint

Lymphedema
Lower Extremity
Exercise
Therapeutics
Skin
Second Primary Neoplasms
Palpation
Bandages
Visual Analog Scale
Cross-Over Studies
Germany
Analysis of Variance
Randomized Controlled Trials

Keywords

  • Ergometer exercise
  • Gynecological cancer
  • Lymphatic system insufficiency
  • Rehabilitation

ASJC Scopus subject areas

  • Oncology

Cite this

Immediate effects of active exercise with compression therapy on lower-limb lymphedema. / Fukushima, Takuya; Tsuji, Tetsuya; Sano, Yufuko; Miyata, Chieko; Kamisako, Michiyo; Hohri, Hiroka; Yoshimura, Chikako; Asakura, Megumi; Okitsu, Taro; Muraoka, Kaori; Liu, Meigen.

In: Supportive Care in Cancer, 06.04.2017, p. 1-8.

Research output: Contribution to journalArticle

Fukushima, T, Tsuji, T, Sano, Y, Miyata, C, Kamisako, M, Hohri, H, Yoshimura, C, Asakura, M, Okitsu, T, Muraoka, K & Liu, M 2017, 'Immediate effects of active exercise with compression therapy on lower-limb lymphedema', Supportive Care in Cancer, pp. 1-8. https://doi.org/10.1007/s00520-017-3671-2
Fukushima, Takuya ; Tsuji, Tetsuya ; Sano, Yufuko ; Miyata, Chieko ; Kamisako, Michiyo ; Hohri, Hiroka ; Yoshimura, Chikako ; Asakura, Megumi ; Okitsu, Taro ; Muraoka, Kaori ; Liu, Meigen. / Immediate effects of active exercise with compression therapy on lower-limb lymphedema. In: Supportive Care in Cancer. 2017 ; pp. 1-8.
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abstract = "Purpose: Active exercise with compression therapy (AECT) is a standard treatment for gynecological cancer-related lower-limb lymphedema (LLL) in clinical situations. However, there is insufficient evidence regarding the immediate effects of the use of AECT on LLL. The purpose of this study was to evaluate the immediate effects of AECT on LLL. Methods: Participants in this randomized controlled crossover trial comprised 23 women with LLL who completed high-load AECT, low-load AECT, and compression-only therapy (CT). AECT was performed on a bicycle ergometer with short stretch bandages. Each intervention was performed for 15 min, with successive interventions separated by a 1-week washout period. Lower-limb volume was assessed using a Perometer™ sensor (Pero-system, Wuppertal, Germany). General symptoms (pain and heaviness) and skin symptoms (pitting and stiffness) were assessed using a visual analog scale and palpation, respectively. Measurements were taken before and after each intervention. Analysis of variance using linear mixed-effect modeling was used for statistical analyses. Results: Volume decrement differed significantly between all three interventions (P < 0.05). Lower-limb volume was significantly reduced after high-load AECT compared to that after CT. General symptoms and skin symptoms were similar across the three interventions, but severity of pre-intervention skin symptoms correlated significantly with volume decrement after high- and low-load AECT. High-load AECT using the bicycle ergometer was more effective than CT for decreasing lower-limb volume. Conclusions: These results suggest that high-load AECT has marked effects on severe LLL.",
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AU - Fukushima, Takuya

AU - Tsuji, Tetsuya

AU - Sano, Yufuko

AU - Miyata, Chieko

AU - Kamisako, Michiyo

AU - Hohri, Hiroka

AU - Yoshimura, Chikako

AU - Asakura, Megumi

AU - Okitsu, Taro

AU - Muraoka, Kaori

AU - Liu, Meigen

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N2 - Purpose: Active exercise with compression therapy (AECT) is a standard treatment for gynecological cancer-related lower-limb lymphedema (LLL) in clinical situations. However, there is insufficient evidence regarding the immediate effects of the use of AECT on LLL. The purpose of this study was to evaluate the immediate effects of AECT on LLL. Methods: Participants in this randomized controlled crossover trial comprised 23 women with LLL who completed high-load AECT, low-load AECT, and compression-only therapy (CT). AECT was performed on a bicycle ergometer with short stretch bandages. Each intervention was performed for 15 min, with successive interventions separated by a 1-week washout period. Lower-limb volume was assessed using a Perometer™ sensor (Pero-system, Wuppertal, Germany). General symptoms (pain and heaviness) and skin symptoms (pitting and stiffness) were assessed using a visual analog scale and palpation, respectively. Measurements were taken before and after each intervention. Analysis of variance using linear mixed-effect modeling was used for statistical analyses. Results: Volume decrement differed significantly between all three interventions (P < 0.05). Lower-limb volume was significantly reduced after high-load AECT compared to that after CT. General symptoms and skin symptoms were similar across the three interventions, but severity of pre-intervention skin symptoms correlated significantly with volume decrement after high- and low-load AECT. High-load AECT using the bicycle ergometer was more effective than CT for decreasing lower-limb volume. Conclusions: These results suggest that high-load AECT has marked effects on severe LLL.

AB - Purpose: Active exercise with compression therapy (AECT) is a standard treatment for gynecological cancer-related lower-limb lymphedema (LLL) in clinical situations. However, there is insufficient evidence regarding the immediate effects of the use of AECT on LLL. The purpose of this study was to evaluate the immediate effects of AECT on LLL. Methods: Participants in this randomized controlled crossover trial comprised 23 women with LLL who completed high-load AECT, low-load AECT, and compression-only therapy (CT). AECT was performed on a bicycle ergometer with short stretch bandages. Each intervention was performed for 15 min, with successive interventions separated by a 1-week washout period. Lower-limb volume was assessed using a Perometer™ sensor (Pero-system, Wuppertal, Germany). General symptoms (pain and heaviness) and skin symptoms (pitting and stiffness) were assessed using a visual analog scale and palpation, respectively. Measurements were taken before and after each intervention. Analysis of variance using linear mixed-effect modeling was used for statistical analyses. Results: Volume decrement differed significantly between all three interventions (P < 0.05). Lower-limb volume was significantly reduced after high-load AECT compared to that after CT. General symptoms and skin symptoms were similar across the three interventions, but severity of pre-intervention skin symptoms correlated significantly with volume decrement after high- and low-load AECT. High-load AECT using the bicycle ergometer was more effective than CT for decreasing lower-limb volume. Conclusions: These results suggest that high-load AECT has marked effects on severe LLL.

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KW - Rehabilitation

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