TY - JOUR
T1 - Immobilization of Natural Products on Glass Slides by Using a Photoaffinity Reaction and the Detection of Protein-Small-Molecule Interactions
AU - Kanoh, Naoki
AU - Kumashiro, Saori
AU - Simizu, Siro
AU - Kondoh, Yasumitsu
AU - Hatakeyama, Satoru
AU - Tashiro, Hideo
AU - Osada, Hiroyuki
PY - 2003/11/24
Y1 - 2003/11/24
N2 - Library on a glass slide: A variety of small molecules, including complex natural products, are introduced to glass slides using a photoaffinity reaction (see picture). The small molecules retain the inherent ability to interact with the relevant binding proteins. Importantly, this immobilization procedure does not require a specific functional group, and can be applied for use with a diverse small-molecule library.
AB - Library on a glass slide: A variety of small molecules, including complex natural products, are introduced to glass slides using a photoaffinity reaction (see picture). The small molecules retain the inherent ability to interact with the relevant binding proteins. Importantly, this immobilization procedure does not require a specific functional group, and can be applied for use with a diverse small-molecule library.
KW - High-throughput screening
KW - Immobilization
KW - Natural products
KW - Photochemistry
KW - Protein-ligand interactions
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U2 - 10.1002/anie.200352164
DO - 10.1002/anie.200352164
M3 - Article
C2 - 14639721
AN - SCOPUS:0344667656
SN - 1433-7851
VL - 42
SP - 5584
EP - 5587
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 45
ER -