Immune and Inflammatory Networks in Myocardial Infarction: Current Research and Its Potential Implications for the Clinic

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1 Citation (Scopus)

Abstract

Despite recent scientific and technological advances, myocardial infarction (MI) still repre-sents a major global health problem, leading to high morbidity and mortality worldwide. During the post-MI wound healing process, dysregulated immune inflammatory pathways and failure to resolve inflammation are associated with maladaptive left ventricular remodeling, progressive heart failure, and eventually poor outcomes. Given the roles of immune cells in the host response against tissue injury, understanding the involved cellular subsets, sources, and functions is essential for discovering novel therapeutic strategies that preserve the protective immune system and promote optimal healing. This review discusses the cellular effectors and molecular signals across multi-organ systems, which regulate the inflammatory and reparative responses after MI. Additionally, we summarize the recent clinical and preclinical data that propel conceptual revolutions in cardiovascular immunotherapy.

Original languageEnglish
Article number5214
JournalInternational journal of molecular sciences
Volume23
Issue number9
DOIs
Publication statusPublished - 2022 May 1

Keywords

  • adaptive immunity
  • chemokines
  • clinical trial
  • clonal hematopoiesis
  • cytokines
  • growth factors
  • heart failure
  • hematopoiesis
  • immune cells
  • immunotherapy
  • inflammation
  • innate immunity
  • myocardial infarction

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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