Immune-mediated neuropathy with anti-disialosyl IgM antibodies in diffuse large B-cell lymphoma: A case report and literature review

Gen Shihashi, Takuya Yagi, Shigeaki Suzuki, Morinobu Seki, Sumiko Kohashi, Tomoki Ueda, Kaori Kameyama, Susumu Kusunoki, Hideaki Nakajima, Shinichiro Okamoto, Norihiro Suzuki

Research output: Contribution to journalArticle

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Abstract

A 36-year-old man with diffuse large B-cell lymphoma presented with polyneuropathy, and the diagnostic work-up revealed the presence of IgM antibodies against gangliosides with disialosyl residues (GD1b, GD3). He was treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone and received high-dose intravenous immunoglobulin for the treatment of neuropathy. After initiating the treatments, the patient's neurological impairment improved dramatically. He currently remains in complete remission without a flare-up of the polyneuropathy. Based upon our experience and other case reports of lymphoma with immune-mediated neuropathy caused by anti-disialosyl ganglioside IgM antibodies, we conclude that determining the anti-ganglioside antibody profile and beginning early treatment should be considered promptly for patients with malignant lymphoma who develop polyneuropathy.

Original languageEnglish
Pages (from-to)1647-1651
Number of pages5
JournalInternal Medicine
Volume54
Issue number13
DOIs
Publication statusPublished - 2015 Jul 1

Fingerprint

Lymphoma, Large B-Cell, Diffuse
Polyneuropathies
Gangliosides
Immunoglobulin M
Antibodies
Lymphoma
Intravenous Immunoglobulins
Vincristine
Prednisone
Doxorubicin
Cyclophosphamide
Anti-Idiotypic Antibodies
Therapeutics
anti-IgM

Keywords

  • Anti-ganglioside antibody
  • Diffuse large B-cell lymphoma
  • Guillain-Barré syndrome
  • Immune-mediated neuropathy
  • Malignant lymphoma
  • Paraneoplastic syndrome

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Immune-mediated neuropathy with anti-disialosyl IgM antibodies in diffuse large B-cell lymphoma : A case report and literature review. / Shihashi, Gen; Yagi, Takuya; Suzuki, Shigeaki; Seki, Morinobu; Kohashi, Sumiko; Ueda, Tomoki; Kameyama, Kaori; Kusunoki, Susumu; Nakajima, Hideaki; Okamoto, Shinichiro; Suzuki, Norihiro.

In: Internal Medicine, Vol. 54, No. 13, 01.07.2015, p. 1647-1651.

Research output: Contribution to journalArticle

Shihashi, Gen ; Yagi, Takuya ; Suzuki, Shigeaki ; Seki, Morinobu ; Kohashi, Sumiko ; Ueda, Tomoki ; Kameyama, Kaori ; Kusunoki, Susumu ; Nakajima, Hideaki ; Okamoto, Shinichiro ; Suzuki, Norihiro. / Immune-mediated neuropathy with anti-disialosyl IgM antibodies in diffuse large B-cell lymphoma : A case report and literature review. In: Internal Medicine. 2015 ; Vol. 54, No. 13. pp. 1647-1651.
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