Immune recognition and rejection of allogeneic skin grafts

Gilles Benichou, Yohei Yamada, Seok Hyun Yun, Charles Lin, Michael Fray, Georges Tocco

Research output: Contribution to journalReview article

55 Citations (Scopus)

Abstract

The transplantation of allogeneic skin grafts is associated with a potent inflammatory immune response leading to the destruction of donor cells and the rejection of the graft. Shortly after transplantation, skin dendritic cells (DCs) migrate out of the graft through lymphatic vessels and infiltrate the recipient's draining lymph nodes where they present donor antigens via two mechanisms: the direct pathway, in which T cells recognize intact donor MHC antigens on donor DCs; and the indirect pathway, involving T-cell recognition of donor peptides bound to self-MHC molecules on recipient DCs. Some recent studies have suggested that T cells can become activated via recognition of donor MHC molecules transferred on recipient antigen-presenting cells (semidirect pathway). Activation of T cells via direct or indirect allorecognition is sufficient to trigger acute rejection of allogeneic skin grafts. In addition, allospecific antibodies contribute to the rejection process either by killing allogeneic targets in a complement-dependent fashion or by opsonizing donor cells and forming immune complexes. Finally, several studies demonstrate that NK cells, activated due to missing self-MHC class I molecules on allogeneic cells, are involved in allogeneic skin graft rejection via direct killing of donor cells and through the production of proinflammatory cytokines including IFN-γ and TNF-α.

Original languageEnglish
Pages (from-to)757-770
Number of pages14
JournalImmunotherapy
Volume3
Issue number6
DOIs
Publication statusPublished - 2011 Jun
Externally publishedYes

Fingerprint

T-Lymphocytes
Transplants
Skin
Graft Rejection
Dendritic Cells
Antigens
Skin Transplantation
Lymphatic Vessels
Langerhans Cells
Homologous Transplantation
Antigen-Presenting Cells
Antigen-Antibody Complex
Natural Killer Cells
Transplantation
Lymph Nodes
Cytokines
Peptides
Antibodies

Keywords

  • allorecognition
  • B lymphocytes
  • NK cells
  • passenger leukocytes
  • skin transplantation
  • T lymphocytes
  • transplant rejection

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

Cite this

Benichou, G., Yamada, Y., Yun, S. H., Lin, C., Fray, M., & Tocco, G. (2011). Immune recognition and rejection of allogeneic skin grafts. Immunotherapy, 3(6), 757-770. https://doi.org/10.2217/imt.11.2

Immune recognition and rejection of allogeneic skin grafts. / Benichou, Gilles; Yamada, Yohei; Yun, Seok Hyun; Lin, Charles; Fray, Michael; Tocco, Georges.

In: Immunotherapy, Vol. 3, No. 6, 06.2011, p. 757-770.

Research output: Contribution to journalReview article

Benichou, G, Yamada, Y, Yun, SH, Lin, C, Fray, M & Tocco, G 2011, 'Immune recognition and rejection of allogeneic skin grafts', Immunotherapy, vol. 3, no. 6, pp. 757-770. https://doi.org/10.2217/imt.11.2
Benichou G, Yamada Y, Yun SH, Lin C, Fray M, Tocco G. Immune recognition and rejection of allogeneic skin grafts. Immunotherapy. 2011 Jun;3(6):757-770. https://doi.org/10.2217/imt.11.2
Benichou, Gilles ; Yamada, Yohei ; Yun, Seok Hyun ; Lin, Charles ; Fray, Michael ; Tocco, Georges. / Immune recognition and rejection of allogeneic skin grafts. In: Immunotherapy. 2011 ; Vol. 3, No. 6. pp. 757-770.
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