Immune regulation by protein ubiquitination: roles of the E3 ligases VHL and Itch

Daisuke Aki, Qian Li, Hui Li, Yun Cai Liu, Jee Ho Lee

Research output: Contribution to journalReview article

Abstract

Protein ubiquitination is an important means of post-translational modification which plays an essential role in the regulation of various aspects of leukocyte development and function. The specificity of ubiquitin tagging to a protein substrate is determined by E3 ubiquitin ligases via defined E3-substrate interactions. In this review, we will focus on two E3 ligases, VHL and Itch, to discuss the latest progress in understanding their roles in the differentiation and function of CD4+ T helper cell subsets, the stability of regulatory T cells, effector function of CD8+ T cells, as well as the development and maturation of innate lymphoid cells. The biological implications of these E3 ubiquitin ligases will be highlighted in the context of normal and dysregulated immune responses including the control of homeostasis, inflammation, auto-immune responses and anti-tumor immunity. Further elucidation of the ubiquitin system in immune cells will help in the design of new therapeutic interventions for human immunological diseases and cancer.

Original languageEnglish
Pages (from-to)395-404
Number of pages10
JournalProtein and Cell
Volume10
Issue number6
DOIs
Publication statusPublished - 2019 Jun 1
Externally publishedYes

Keywords

  • Cbl-b
  • E3 ligase
  • HIF
  • Itch
  • VHL
  • WWP2
  • autoimmunity
  • inflammation
  • ubiquitin

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Drug Discovery
  • Cell Biology

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