Abstract
A variety of molecules involved in the immune system have recently been isolated. These molecules have allowed the design of immunological interventions of immune responses to human cancer, or so called immuno-gene therapy. Clinical trials have been performed in Europe and the U.S. using various protocols, including gene-modified T cells; highly immunogenic cancer cells transfected with genes encoding cytokines, co-stimulatory molecules, and foreign antigens; immunization with tumor antigen genes as forms of plasmids and recombinant viruses; and immunization with dendritic cells transduced with tumor antigen genes. However, the anti-tumor effects observed in these reports have been limited. Improvement of various points will be necessary to establish immuno-gene therapy for cancer on the basis of fundamental research on immunoregulation against cancer, including isolation of tumor antigens and analysis of tumor escape mechanisms.
| Original language | English |
|---|---|
| Pages (from-to) | 345-350 |
| Number of pages | 6 |
| Journal | Biotherapy |
| Volume | 14 |
| Issue number | 4 |
| Publication status | Published - 2000 |
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Keywords
- Cytokines
- Dendritic cells
- DNA immunization
- Recombinant viruses
- Tumor antigens
ASJC Scopus subject areas
- Cancer Research
- Immunology and Allergy
Cite this
Immuno-gene therapy for cancer. / Kawakami, Yutaka.
In: Biotherapy, Vol. 14, No. 4, 2000, p. 345-350.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immuno-gene therapy for cancer
AU - Kawakami, Yutaka
PY - 2000
Y1 - 2000
N2 - A variety of molecules involved in the immune system have recently been isolated. These molecules have allowed the design of immunological interventions of immune responses to human cancer, or so called immuno-gene therapy. Clinical trials have been performed in Europe and the U.S. using various protocols, including gene-modified T cells; highly immunogenic cancer cells transfected with genes encoding cytokines, co-stimulatory molecules, and foreign antigens; immunization with tumor antigen genes as forms of plasmids and recombinant viruses; and immunization with dendritic cells transduced with tumor antigen genes. However, the anti-tumor effects observed in these reports have been limited. Improvement of various points will be necessary to establish immuno-gene therapy for cancer on the basis of fundamental research on immunoregulation against cancer, including isolation of tumor antigens and analysis of tumor escape mechanisms.
AB - A variety of molecules involved in the immune system have recently been isolated. These molecules have allowed the design of immunological interventions of immune responses to human cancer, or so called immuno-gene therapy. Clinical trials have been performed in Europe and the U.S. using various protocols, including gene-modified T cells; highly immunogenic cancer cells transfected with genes encoding cytokines, co-stimulatory molecules, and foreign antigens; immunization with tumor antigen genes as forms of plasmids and recombinant viruses; and immunization with dendritic cells transduced with tumor antigen genes. However, the anti-tumor effects observed in these reports have been limited. Improvement of various points will be necessary to establish immuno-gene therapy for cancer on the basis of fundamental research on immunoregulation against cancer, including isolation of tumor antigens and analysis of tumor escape mechanisms.
KW - Cytokines
KW - Dendritic cells
KW - DNA immunization
KW - Recombinant viruses
KW - Tumor antigens
UR - http://www.scopus.com/inward/record.url?scp=0034071445&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034071445&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0034071445
VL - 14
SP - 345
EP - 350
JO - Biotherapy
JF - Biotherapy
SN - 0914-2223
IS - 4
ER -