Immuno-gene therapy for cancer

Yutaka Kawakami

Research output: Contribution to journalArticle

Abstract

A variety of molecules involved in the immune system have recently been isolated. These molecules have allowed the design of immunological interventions of immune responses to human cancer, or so called immuno-gene therapy. Clinical trials have been performed in Europe and the U.S. using various protocols, including gene-modified T cells; highly immunogenic cancer cells transfected with genes encoding cytokines, co-stimulatory molecules, and foreign antigens; immunization with tumor antigen genes as forms of plasmids and recombinant viruses; and immunization with dendritic cells transduced with tumor antigen genes. However, the anti-tumor effects observed in these reports have been limited. Improvement of various points will be necessary to establish immuno-gene therapy for cancer on the basis of fundamental research on immunoregulation against cancer, including isolation of tumor antigens and analysis of tumor escape mechanisms.

Original languageEnglish
Pages (from-to)345-350
Number of pages6
JournalBiotherapy
Volume14
Issue number4
Publication statusPublished - 2000

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Genetic Therapy
Neoplasm Antigens
Neoplasms
Genes
Immunization
Tumor Escape
Dendritic Cells
Immune System
Plasmids
Clinical Trials
Cytokines
Viruses
T-Lymphocytes
Antigens
Research

Keywords

  • Cytokines
  • Dendritic cells
  • DNA immunization
  • Recombinant viruses
  • Tumor antigens

ASJC Scopus subject areas

  • Cancer Research
  • Immunology and Allergy

Cite this

Kawakami, Y. (2000). Immuno-gene therapy for cancer. Biotherapy, 14(4), 345-350.

Immuno-gene therapy for cancer. / Kawakami, Yutaka.

In: Biotherapy, Vol. 14, No. 4, 2000, p. 345-350.

Research output: Contribution to journalArticle

Kawakami, Y 2000, 'Immuno-gene therapy for cancer', Biotherapy, vol. 14, no. 4, pp. 345-350.
Kawakami Y. Immuno-gene therapy for cancer. Biotherapy. 2000;14(4):345-350.
Kawakami, Yutaka. / Immuno-gene therapy for cancer. In: Biotherapy. 2000 ; Vol. 14, No. 4. pp. 345-350.
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