Immunochemotherapy prevents human colon cancer metastasis after orthotopic onplantation of histologically-intact tumor tissue in nude mice

T. Furukawa, T. Kubota, M. Watanabe, T. H. Kuo, S. Kase, Yoshirou Saikawa, H. Tanino, T. Teramoto, K. Ishibiki, M. Kitajima, R. M. Hoffman

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13 Citations (Scopus)

Abstract

A metastatic model of human colon cancer has been previously established using orthotopic onplantation of histologically intact in tissue nude mice. In this study, effects of immunochemotherapy using OK-432, 5-fluorouracil (5-FU) and mitomycin C (MMC) on Col-2-JCK, a human colon cancer xenograft, were evaluated using this model. When 5-FU and MMC were administered without OK-432, liver metastases were not reduced even at maximum tolerated doses of both drugs, although cecal tumor growth was significantly reduced. On the other hand, when combined with OK-432, both 5-FU and MMC reduced liver metastases with synergistic reduction of cecal tumor growth, demonstrating the potential of combining immunotherapy with chemotherapy against metastases.

Original languageEnglish
Pages (from-to)287-291
Number of pages5
JournalAnticancer research
Volume13
Issue number2
Publication statusPublished - 1993 Jan 1

Keywords

  • Colon cancer
  • Immunotherapy
  • Metastasis
  • Nude mice
  • Onplantation
  • Orthotopic

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Furukawa, T., Kubota, T., Watanabe, M., Kuo, T. H., Kase, S., Saikawa, Y., Tanino, H., Teramoto, T., Ishibiki, K., Kitajima, M., & Hoffman, R. M. (1993). Immunochemotherapy prevents human colon cancer metastasis after orthotopic onplantation of histologically-intact tumor tissue in nude mice. Anticancer research, 13(2), 287-291.