Immunochemotherapy prevents human colon cancer metastasis after orthotopic onplantation of histologically-intact tumor tissue in nude mice

Toshiharu Furukawa, T. Kubota, M. Watanabe, T. H. Kuo, S. Kase, Y. Saikawa, H. Tanino, T. Teramoto, K. Ishibiki, M. Kitajima, R. M. Hoffman

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A metastatic model of human colon cancer has been previously established using orthotopic onplantation of histologically intact in tissue nude mice. In this study, effects of immunochemotherapy using OK-432, 5-fluorouracil (5-FU) and mitomycin C (MMC) on Col-2-JCK, a human colon cancer xenograft, were evaluated using this model. When 5-FU and MMC were administered without OK-432, liver metastases were not reduced even at maximum tolerated doses of both drugs, although cecal tumor growth was significantly reduced. On the other hand, when combined with OK-432, both 5-FU and MMC reduced liver metastases with synergistic reduction of cecal tumor growth, demonstrating the potential of combining immunotherapy with chemotherapy against metastases.

Original languageEnglish
Pages (from-to)287-291
Number of pages5
JournalAnticancer Research
Volume13
Issue number2
Publication statusPublished - 1993

Fingerprint

Picibanil
Mitomycin
Nude Mice
Fluorouracil
Colonic Neoplasms
Neoplasm Metastasis
Neoplasms
Maximum Tolerated Dose
Liver
Growth
Heterografts
Immunotherapy
Drug Therapy
Pharmaceutical Preparations

Keywords

  • Colon cancer
  • Immunotherapy
  • Metastasis
  • Nude mice
  • Onplantation
  • Orthotopic

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Immunochemotherapy prevents human colon cancer metastasis after orthotopic onplantation of histologically-intact tumor tissue in nude mice. / Furukawa, Toshiharu; Kubota, T.; Watanabe, M.; Kuo, T. H.; Kase, S.; Saikawa, Y.; Tanino, H.; Teramoto, T.; Ishibiki, K.; Kitajima, M.; Hoffman, R. M.

In: Anticancer Research, Vol. 13, No. 2, 1993, p. 287-291.

Research output: Contribution to journalArticle

Furukawa, T, Kubota, T, Watanabe, M, Kuo, TH, Kase, S, Saikawa, Y, Tanino, H, Teramoto, T, Ishibiki, K, Kitajima, M & Hoffman, RM 1993, 'Immunochemotherapy prevents human colon cancer metastasis after orthotopic onplantation of histologically-intact tumor tissue in nude mice', Anticancer Research, vol. 13, no. 2, pp. 287-291.
Furukawa, Toshiharu ; Kubota, T. ; Watanabe, M. ; Kuo, T. H. ; Kase, S. ; Saikawa, Y. ; Tanino, H. ; Teramoto, T. ; Ishibiki, K. ; Kitajima, M. ; Hoffman, R. M. / Immunochemotherapy prevents human colon cancer metastasis after orthotopic onplantation of histologically-intact tumor tissue in nude mice. In: Anticancer Research. 1993 ; Vol. 13, No. 2. pp. 287-291.
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