Immunochemotherapy prevents human colon cancer metastasis after orthotopic onplantation of histologically-intact tumor tissue in nude mice

T. Furukawa; T. Kubota; M. Watanabe; T. H. Kuo; S. Kase; Yoshirou Saikawa; H. Tanino; T. Teramoto; K. Ishibiki; M. Kitajima; R. M. Hoffman

Immunochemotherapy prevents human colon cancer metastasis after orthotopic onplantation of histologically-intact tumor tissue in nude mice

T. Furukawa, T. Kubota, M. Watanabe, T. H. Kuo, S. Kase, Yoshirou Saikawa, H. Tanino, T. Teramoto, K. Ishibiki, M. Kitajima, R. M. Hoffman

Law School

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

A metastatic model of human colon cancer has been previously established using orthotopic onplantation of histologically intact in tissue nude mice. In this study, effects of immunochemotherapy using OK-432, 5-fluorouracil (5-FU) and mitomycin C (MMC) on Col-2-JCK, a human colon cancer xenograft, were evaluated using this model. When 5-FU and MMC were administered without OK-432, liver metastases were not reduced even at maximum tolerated doses of both drugs, although cecal tumor growth was significantly reduced. On the other hand, when combined with OK-432, both 5-FU and MMC reduced liver metastases with synergistic reduction of cecal tumor growth, demonstrating the potential of combining immunotherapy with chemotherapy against metastases.

Original language	English
Pages (from-to)	287-291
Number of pages	5
Journal	Anticancer research
Volume	13
Issue number	2
Publication status	Published - 1993 Jan 1

Keywords

Colon cancer
Immunotherapy
Metastasis
Nude mice
Onplantation
Orthotopic

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Immunochemotherapy prevents human colon cancer metastasis after orthotopic onplantation of histologically-intact tumor tissue in nude mice",

abstract = "A metastatic model of human colon cancer has been previously established using orthotopic onplantation of histologically intact in tissue nude mice. In this study, effects of immunochemotherapy using OK-432, 5-fluorouracil (5-FU) and mitomycin C (MMC) on Col-2-JCK, a human colon cancer xenograft, were evaluated using this model. When 5-FU and MMC were administered without OK-432, liver metastases were not reduced even at maximum tolerated doses of both drugs, although cecal tumor growth was significantly reduced. On the other hand, when combined with OK-432, both 5-FU and MMC reduced liver metastases with synergistic reduction of cecal tumor growth, demonstrating the potential of combining immunotherapy with chemotherapy against metastases.",

keywords = "Colon cancer, Immunotherapy, Metastasis, Nude mice, Onplantation, Orthotopic",

author = "T. Furukawa and T. Kubota and M. Watanabe and Kuo, {T. H.} and S. Kase and Yoshirou Saikawa and H. Tanino and T. Teramoto and K. Ishibiki and M. Kitajima and Hoffman, {R. M.}",

year = "1993",

month = jan,

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language = "English",

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pages = "287--291",

journal = "Anticancer Research",

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T1 - Immunochemotherapy prevents human colon cancer metastasis after orthotopic onplantation of histologically-intact tumor tissue in nude mice

AU - Furukawa, T.

AU - Kubota, T.

AU - Watanabe, M.

AU - Kuo, T. H.

AU - Kase, S.

AU - Saikawa, Yoshirou

AU - Tanino, H.

AU - Teramoto, T.

AU - Ishibiki, K.

AU - Kitajima, M.

AU - Hoffman, R. M.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - A metastatic model of human colon cancer has been previously established using orthotopic onplantation of histologically intact in tissue nude mice. In this study, effects of immunochemotherapy using OK-432, 5-fluorouracil (5-FU) and mitomycin C (MMC) on Col-2-JCK, a human colon cancer xenograft, were evaluated using this model. When 5-FU and MMC were administered without OK-432, liver metastases were not reduced even at maximum tolerated doses of both drugs, although cecal tumor growth was significantly reduced. On the other hand, when combined with OK-432, both 5-FU and MMC reduced liver metastases with synergistic reduction of cecal tumor growth, demonstrating the potential of combining immunotherapy with chemotherapy against metastases.

AB - A metastatic model of human colon cancer has been previously established using orthotopic onplantation of histologically intact in tissue nude mice. In this study, effects of immunochemotherapy using OK-432, 5-fluorouracil (5-FU) and mitomycin C (MMC) on Col-2-JCK, a human colon cancer xenograft, were evaluated using this model. When 5-FU and MMC were administered without OK-432, liver metastases were not reduced even at maximum tolerated doses of both drugs, although cecal tumor growth was significantly reduced. On the other hand, when combined with OK-432, both 5-FU and MMC reduced liver metastases with synergistic reduction of cecal tumor growth, demonstrating the potential of combining immunotherapy with chemotherapy against metastases.

KW - Colon cancer

KW - Immunotherapy

KW - Metastasis

KW - Nude mice

KW - Onplantation

KW - Orthotopic

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M3 - Article

C2 - 8517641

AN - SCOPUS:0027222749

SN - 0250-7005

VL - 13

SP - 287

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JO - Anticancer Research

JF - Anticancer Research

IS - 2

ER -

Immunochemotherapy prevents human colon cancer metastasis after orthotopic onplantation of histologically-intact tumor tissue in nude mice

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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