Immunohistochemical analysis of SOX6 expression in human brain tumors

Ryo Ueda, Kazunari Yoshida, Yutaka Kawakami, Takeshi Kawase, Masahiro Toda

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We previously demonstrated that the developmentally regulated gene, SOX6, is strongly expressed in glioma cells and in the fetal brain, but only faintly in the normal adult brain. Recent studies have indicated that brain tumor cells may share antigens, signaling systems, and behavior with neural stem/progenitor cells. To test the validity of this proposition, we analyzed the expression of SOX6 in various human central nervous system (CNS) tumors. Immunohistochemical analysis revealed that astrocytic and oligodendroglial tumors expressed SOX6; neuronal-glial cell tumors (central neurocytoma) and embryonal tumors (medulloblastoma), which arise from multipotential stem cell precursors, also showed a high intensity of SOX6 staining. In contrast, ependymal tumors (ependymoma and subependymoma), meningioma, and schwannoma, which are all well differentiated tumors, showed either no staining or only faint staining for SOX6. These results suggest that SOX6 may be expressed in bipotential or multipotential cells capable of neuronal and glial differentiation, but not in fully differentiated cells. SOX6 may be a useful marker for the diagnosis of tumors arising from immature bipotential cells that may differentiate into neuronal and glial cells.

Original languageEnglish
Pages (from-to)117-120
Number of pages4
JournalBrain Tumor Pathology
Volume21
Issue number3
DOIs
Publication statusPublished - 2004

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Brain Neoplasms
Staining and Labeling
Glioma
Neuroglia
Neoplasms
Subependymal Glioma
Stem Cells
Neurocytoma
Ependymoma
Central Nervous System Neoplasms
Medulloblastoma
Neural Stem Cells
Neurilemmoma
Brain
Meningioma
Tumor Biomarkers
Antigens
Genes

Keywords

  • Brain tumor
  • Neural stem/progenitor cell
  • SOX6
  • Undifferentiated cell

ASJC Scopus subject areas

  • Cancer Research
  • Pathology and Forensic Medicine

Cite this

Immunohistochemical analysis of SOX6 expression in human brain tumors. / Ueda, Ryo; Yoshida, Kazunari; Kawakami, Yutaka; Kawase, Takeshi; Toda, Masahiro.

In: Brain Tumor Pathology, Vol. 21, No. 3, 2004, p. 117-120.

Research output: Contribution to journalArticle

Ueda, Ryo ; Yoshida, Kazunari ; Kawakami, Yutaka ; Kawase, Takeshi ; Toda, Masahiro. / Immunohistochemical analysis of SOX6 expression in human brain tumors. In: Brain Tumor Pathology. 2004 ; Vol. 21, No. 3. pp. 117-120.
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