Immunohistochemical determination of immunosuppressive acidic protein in reactive and neoplastic diseases of macrophage

K. Aozasa, T. Ueda, M. Ayata, M. Tsujimoto, Masaki Q Fujita, T. Yamamura, T. Tsujimura

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Immunosuppressive acidic protein (IAP), a substance purified from cancer ascitic fluid, is released into the culture medium of macrophages and neutrophils, and is supposed to suppress an immune function of the host. Elevation of serum IAP in cancer patients has been reported. In the current study, presence of IAP in proliferating diseases of macrophage was examined. Macrophages in reactive proliferation, histiocytosis X, and neoplastic proliferation gave positive reaction for IAP. Diffuse cytoplasmic staining was usual, but dot-like or globular and surface staining also were observed. Proliferating cells in malignant fibrous histiocytoma were more sensitively stained by IAP than by other ordinary used markers for macrophage. These findings provide useful information to understand the mechanism of elevation of serum IAP in cancer patients.

Original languageEnglish
Pages (from-to)2424-2427
Number of pages4
JournalCancer
Volume60
Issue number10
Publication statusPublished - 1987
Externally publishedYes

Fingerprint

Macrophages
Staining and Labeling
Malignant Fibrous Histiocytoma
Neoplasms
Langerhans Cell Histiocytosis
Ascitic Fluid
Serum
Culture Media
immunosuppressive acidic protein
Neutrophils

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Aozasa, K., Ueda, T., Ayata, M., Tsujimoto, M., Fujita, M. Q., Yamamura, T., & Tsujimura, T. (1987). Immunohistochemical determination of immunosuppressive acidic protein in reactive and neoplastic diseases of macrophage. Cancer, 60(10), 2424-2427.

Immunohistochemical determination of immunosuppressive acidic protein in reactive and neoplastic diseases of macrophage. / Aozasa, K.; Ueda, T.; Ayata, M.; Tsujimoto, M.; Fujita, Masaki Q; Yamamura, T.; Tsujimura, T.

In: Cancer, Vol. 60, No. 10, 1987, p. 2424-2427.

Research output: Contribution to journalArticle

Aozasa, K, Ueda, T, Ayata, M, Tsujimoto, M, Fujita, MQ, Yamamura, T & Tsujimura, T 1987, 'Immunohistochemical determination of immunosuppressive acidic protein in reactive and neoplastic diseases of macrophage', Cancer, vol. 60, no. 10, pp. 2424-2427.
Aozasa, K. ; Ueda, T. ; Ayata, M. ; Tsujimoto, M. ; Fujita, Masaki Q ; Yamamura, T. ; Tsujimura, T. / Immunohistochemical determination of immunosuppressive acidic protein in reactive and neoplastic diseases of macrophage. In: Cancer. 1987 ; Vol. 60, No. 10. pp. 2424-2427.
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