Immunohistochemical determination of immunosuppressive acidic protein in reactive and neoplastic diseases of macrophage

Katsuyuki Aozasa, Takafumi Ueda, Masahiro Ayata, Masahiko Tsujimoto, Masaki Q. Fujita, Teiichi Yamamura, Takahiro Tsujimura

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Immunosuppressive acidic protein (IAP), a substance purified from cancer ascitic fluid, is released into the culture medium of macrophages and neutrophils, and is supposed to suppress an immune function of the host. Elevation of serum IAP in cancer patients has been reported. In the current study, presence of IAP in proliferating diseases of macrophage was examined. Macrophages in reactive proliferation, histiocytosis X, and neoplastic proliferation gave positive reaction for IAP. Diffuse cytoplasmic staining was usual, but dot‐like or globular and surface staining also were observed. Proliferating cells in malignant fibrous histiocytoma were more sensitively stained by IAP than by other ordinary used markers for macrophage. These findings provide useful information to understand the mechanism of elevation of serum IAP in cancer patients.

Original languageEnglish
Pages (from-to)2424-2427
Number of pages4
JournalCancer
Volume60
Issue number10
DOIs
Publication statusPublished - 1987 Nov 15
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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