Immunohistochemical investigation of pulmonary surfactant-associated protein A in fire victims

Bao Li Zhu, Kaori Ishida, Shigeki Oritani, Li Quan, Mari Taniguchi, Dong Ri Li, Masaki Q Fujita, Hitoshi Maeda

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

To evaluate the forensic pathological significance of the immunohistochemical distribution of pulmonary surfactant-associated protein A (SP-A) in determining the cause of death in fires, 57 fire victims were examined by scoring the staining intensity. The highest SP-A score with dense granular deposits (aggregates) in the intra-alveolar space was frequently observed in cases with a lower blood carboxyhemoglobin (COHb) level (<60%). The SP-A score was relatively low in carbon monoxide intoxication due to causes other than fires. High SP-A scores showed a relation to the serum level and in part related to the bloody exudate in the lower airway. These observations suggested that the increase in SP-A in fire victims may be mainly related to pulmonary alveolar injury due to the inhalation of hot air and/or irritant gases rather than hypoxia.

Original languageEnglish
Pages (from-to)23-28
Number of pages6
JournalLegal Medicine
Volume3
Issue number1
DOIs
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Pulmonary Surfactant-Associated Protein A
Staphylococcal Protein A
Surface-Active Agents
Carboxyhemoglobin
Irritants
Lung Injury
Exudates and Transudates
Carbon Monoxide
Inhalation
Cause of Death
Gases
Air
Staining and Labeling
Serum

Keywords

  • Carbon monoxide
  • Fire death
  • Forensic pathology
  • Hypoxia
  • Immunohistochemistry
  • Pulmonary surfactant-associated protein A

ASJC Scopus subject areas

  • Genetics
  • Pathology and Forensic Medicine
  • Psychiatry and Mental health
  • Public Health, Environmental and Occupational Health

Cite this

Zhu, B. L., Ishida, K., Oritani, S., Quan, L., Taniguchi, M., Li, D. R., ... Maeda, H. (2001). Immunohistochemical investigation of pulmonary surfactant-associated protein A in fire victims. Legal Medicine, 3(1), 23-28. https://doi.org/10.1016/S1344-6223(01)00006-2

Immunohistochemical investigation of pulmonary surfactant-associated protein A in fire victims. / Zhu, Bao Li; Ishida, Kaori; Oritani, Shigeki; Quan, Li; Taniguchi, Mari; Li, Dong Ri; Fujita, Masaki Q; Maeda, Hitoshi.

In: Legal Medicine, Vol. 3, No. 1, 2001, p. 23-28.

Research output: Contribution to journalArticle

Zhu, BL, Ishida, K, Oritani, S, Quan, L, Taniguchi, M, Li, DR, Fujita, MQ & Maeda, H 2001, 'Immunohistochemical investigation of pulmonary surfactant-associated protein A in fire victims', Legal Medicine, vol. 3, no. 1, pp. 23-28. https://doi.org/10.1016/S1344-6223(01)00006-2
Zhu, Bao Li ; Ishida, Kaori ; Oritani, Shigeki ; Quan, Li ; Taniguchi, Mari ; Li, Dong Ri ; Fujita, Masaki Q ; Maeda, Hitoshi. / Immunohistochemical investigation of pulmonary surfactant-associated protein A in fire victims. In: Legal Medicine. 2001 ; Vol. 3, No. 1. pp. 23-28.
@article{c36fc6f13aa2410c8a104fc6fa37058e,
title = "Immunohistochemical investigation of pulmonary surfactant-associated protein A in fire victims",
abstract = "To evaluate the forensic pathological significance of the immunohistochemical distribution of pulmonary surfactant-associated protein A (SP-A) in determining the cause of death in fires, 57 fire victims were examined by scoring the staining intensity. The highest SP-A score with dense granular deposits (aggregates) in the intra-alveolar space was frequently observed in cases with a lower blood carboxyhemoglobin (COHb) level (<60{\%}). The SP-A score was relatively low in carbon monoxide intoxication due to causes other than fires. High SP-A scores showed a relation to the serum level and in part related to the bloody exudate in the lower airway. These observations suggested that the increase in SP-A in fire victims may be mainly related to pulmonary alveolar injury due to the inhalation of hot air and/or irritant gases rather than hypoxia.",
keywords = "Carbon monoxide, Fire death, Forensic pathology, Hypoxia, Immunohistochemistry, Pulmonary surfactant-associated protein A",
author = "Zhu, {Bao Li} and Kaori Ishida and Shigeki Oritani and Li Quan and Mari Taniguchi and Li, {Dong Ri} and Fujita, {Masaki Q} and Hitoshi Maeda",
year = "2001",
doi = "10.1016/S1344-6223(01)00006-2",
language = "English",
volume = "3",
pages = "23--28",
journal = "Legal Medicine",
issn = "1344-6223",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Immunohistochemical investigation of pulmonary surfactant-associated protein A in fire victims

AU - Zhu, Bao Li

AU - Ishida, Kaori

AU - Oritani, Shigeki

AU - Quan, Li

AU - Taniguchi, Mari

AU - Li, Dong Ri

AU - Fujita, Masaki Q

AU - Maeda, Hitoshi

PY - 2001

Y1 - 2001

N2 - To evaluate the forensic pathological significance of the immunohistochemical distribution of pulmonary surfactant-associated protein A (SP-A) in determining the cause of death in fires, 57 fire victims were examined by scoring the staining intensity. The highest SP-A score with dense granular deposits (aggregates) in the intra-alveolar space was frequently observed in cases with a lower blood carboxyhemoglobin (COHb) level (<60%). The SP-A score was relatively low in carbon monoxide intoxication due to causes other than fires. High SP-A scores showed a relation to the serum level and in part related to the bloody exudate in the lower airway. These observations suggested that the increase in SP-A in fire victims may be mainly related to pulmonary alveolar injury due to the inhalation of hot air and/or irritant gases rather than hypoxia.

AB - To evaluate the forensic pathological significance of the immunohistochemical distribution of pulmonary surfactant-associated protein A (SP-A) in determining the cause of death in fires, 57 fire victims were examined by scoring the staining intensity. The highest SP-A score with dense granular deposits (aggregates) in the intra-alveolar space was frequently observed in cases with a lower blood carboxyhemoglobin (COHb) level (<60%). The SP-A score was relatively low in carbon monoxide intoxication due to causes other than fires. High SP-A scores showed a relation to the serum level and in part related to the bloody exudate in the lower airway. These observations suggested that the increase in SP-A in fire victims may be mainly related to pulmonary alveolar injury due to the inhalation of hot air and/or irritant gases rather than hypoxia.

KW - Carbon monoxide

KW - Fire death

KW - Forensic pathology

KW - Hypoxia

KW - Immunohistochemistry

KW - Pulmonary surfactant-associated protein A

UR - http://www.scopus.com/inward/record.url?scp=0035061062&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035061062&partnerID=8YFLogxK

U2 - 10.1016/S1344-6223(01)00006-2

DO - 10.1016/S1344-6223(01)00006-2

M3 - Article

VL - 3

SP - 23

EP - 28

JO - Legal Medicine

JF - Legal Medicine

SN - 1344-6223

IS - 1

ER -