Immunohistochemical investigation of pulmonary surfactant-associated protein A in fire victims

Bao Li Zhu, Kaori Ishida, Shigeki Oritani, Li Quan, Mari Taniguchi, Dong Ri Li, Masaki Q. Fujita, Hitoshi Maeda

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11 Citations (Scopus)


To evaluate the forensic pathological significance of the immunohistochemical distribution of pulmonary surfactant-associated protein A (SP-A) in determining the cause of death in fires, 57 fire victims were examined by scoring the staining intensity. The highest SP-A score with dense granular deposits (aggregates) in the intra-alveolar space was frequently observed in cases with a lower blood carboxyhemoglobin (COHb) level (<60%). The SP-A score was relatively low in carbon monoxide intoxication due to causes other than fires. High SP-A scores showed a relation to the serum level and in part related to the bloody exudate in the lower airway. These observations suggested that the increase in SP-A in fire victims may be mainly related to pulmonary alveolar injury due to the inhalation of hot air and/or irritant gases rather than hypoxia.

Original languageEnglish
Pages (from-to)23-28
Number of pages6
JournalLegal Medicine
Issue number1
Publication statusPublished - 2001
Externally publishedYes


  • Carbon monoxide
  • Fire death
  • Forensic pathology
  • Hypoxia
  • Immunohistochemistry
  • Pulmonary surfactant-associated protein A

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Issues, ethics and legal aspects


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