Immunohistochemical molecular expression profile of metastatic brain tumor for potent personalized medicine

Yasutaka Kato, Hiroshi Nishihara, Sayaka Yuzawa, Hiromi Mohri, Hiromi Kanno, Yutaka Hatanaka, Taichi Kimura, Mishie Tanino, Shinya Tanaka

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Recent progress in molecule-targeting therapy may yield personalized therapeutic strategies for patients with metastatic brain tumors (MBT), the most frequently encountered intracranial tumors. For this purpose, we investigated the molecular expression profile of MBT to establish the pathological basis for personalized diagnosis. We studied 166 MBT specimens including 70 cases of lung cancer and 34 cases of breast cancer, and performed immunostaining for EGFR, COX-2, and O-6-methylguanine-DNA methyltransferase (MGMT), among others, which could be target molecules for therapeutic agents or enable prediction of drug efficacy. Loss of MGMT expression was observed in approximately 20-40 % of MBT derived from lung, breast, and gastrointestinal cancers, indicating the possibility of treatment of MBT patients with temozolomide. In addition, MBT expressed a variety of receptor tyrosine kinases, for example EGFR and HER2, and signal transduction molecules, for example phospho-mTOR and COX-2, irrespective of tumor origin, enabling individualized medication with molecule-targeting drugs. We also identified alteration of molecular expression profile in 4 MBT cases during recurrence. Our results not only reveal the molecular characteristics of MBT but also suggest the possibility of potent personalized medicine for MBT patients.

Original languageEnglish
Pages (from-to)167-174
Number of pages8
JournalBrain tumor pathology
Volume30
Issue number3
DOIs
Publication statusPublished - 2013 Jul

Keywords

  • Immunohistochemistry
  • Metastatic brain tumor
  • Molecular expression profile
  • Personalized medicine

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology
  • Cancer Research

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