Immunohistochemical studies on mouse cerebral cortex grafted into the third ventricle of rats treated with cyclosporin A

Hiroshi Inoue, Shinichi Kohsaka, Kazunari Yoshida, Mitsuhiro Otani, Shigeo Toya, Yasuzo Tsukada

Research output: Contribution to journalArticle

18 Citations (Scopus)


Newborn mouse cerebral cortex was transplanted into the third ventricle of an adult rat brain. After the operation, the immunosuppressant cyclosporin A was administered daily for two weeks, and the grafted tissue was examined immunohistochemically at the 4th week. Neurons, astroglias and oligoden-droglias were positively stained by antibodies against neurofilament, glial fibrillary acid protein and 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase), respectively. The CNPase staining indicated that myelination had occurred in the grafted tissue. Thus both neuronal and glial elements in the grafted tissue could survive and mature in the third ventricle of the different species upon administration of cyclosporin A.

Original languageEnglish
Pages (from-to)289-294
Number of pages6
JournalNeuroscience Letters
Issue number3
Publication statusPublished - 1985 Jun 24



  • 2',3'-cyclic nucleotide 3'-phosphodiesterase
  • CNPase
  • cyclosporin A
  • GFAP
  • glial fibrillary acidic protein
  • immunohistochemistry
  • myelination
  • neural transplantation
  • neurofilament
  • rat

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this