Immunohistochemical study is helpful for the diagnosis of cerebellar clear cell ependymoma with atypical radiological findings: Case report

Takuro Hayashi, Hiromichi Miyazaki, Naomi Ishiyama, Kaori Kameyama

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A 67-year-old male presented with a clear cell ependymoma with symptoms of ataxic gait and dizziness. Magnetic resonance imaging showed a ring enhanced and circumscribed mass lesion with some cysts in the left cerebellar hemisphere, and the vertebral artery angiogram showed the vascurality of the tumor fed by both the left posterior inferior cerebellar artery and the left superior cerebellar artery mainly. They demonstrated suspicious finding of metastatic tumor, glioblastoma, or cystic meningioma. Surgery via the left suboccipital approach revealed a whitish and solid tumor, which was demarcated from the cerebellar parenchyma and had no continuity with the 4th ventricle. Total resection of the tumor was successfully performed. The hematoxilyn-eosin staining of the surgical specimen was similar to hemangioblastoma or oligodendroglioma, however, immunohistochemical findings for glial fibrillary acidic protein, vimentin, epithelial membrane antigen, and factor VI were compatible with clear cell ependymoma. The patient's postoperative course was uneventful, and his symptoms improved. Clear cell ependymoma is known as a variant of ependymoma, which is usually located at the foramen of Monro. We think that the immunohistochemical study is highly helpful for the diagnosis of the cerebellar tumor with atypical presentation such as our case.

Original languageEnglish
Pages (from-to)1113-1117
Number of pages5
JournalNeurological Surgery
Issue number11
Publication statusPublished - 2005 Nov 1



  • Cerebellum
  • Clear cell ependymoma
  • Cyst
  • MRI
  • Ring enhance

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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