Immunohistochemical study of localization of γ-glutamyl transpeptidase in the rat brain

M. Ogawa, M. Shiozawa, Yoshiki Hiraoka, Y. Takeuchi, S. Aiso

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γ-glutamyl transpeptidase (γ-GTP) is a membrane-bound enzyme which is known to play a crucial role in active transport of amino acids across membrane barriers. We prepared a monoclonal antibody recognizing specifically rat γ-GTP and investigated localization of the enzyme in the rat brain by immunohistochemistry with this antibody. The antigen was localized on the ependyma, epithelia of the choroid plexus and microvessels. More precise localization of γ-GTP was examined with immuno-electron microscopy. The antigen was recognized on the microvilli and cilia of the ependymal cells, microvilli of the choroid epithelial cells and luminal membranes of the vascular endothelial cells.

Original languageEnglish
Pages (from-to)597-601
Number of pages5
JournalTissue and Cell
Issue number6
Publication statusPublished - 1998



  • γ-glutamyl transpeptidase
  • Choroid plexus
  • Ependymal cell
  • Immunohistochemistry
  • Vascular endothelial cell

ASJC Scopus subject areas

  • Insect Science
  • Cell Biology

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