Immunohistochemistry of pulmonary surfactant apoprotein A in forensic autopsy: Reassessment in relation to the causes of death

Bao Li Zhu, Kaori Ishida, Li Quan, Masaki Q Fujita, Hitoshi Maeda

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

To reassess the immunohistochemical distribution of pulmonary surfactant apoprotein A (SP-A) in relation to the causes of death, 282 forensic autopsy cases were reviewed. The most intense and dense granular immunostaining of intra-alveolar SP-A was observed in the hyaline membrane syndrome from various traumas, protracted death from drowning, and perinatal aspiration of amniotic fluid. Similar granular staining pattern was found in fatal poisoning by a muscle relaxant and organophosphate pesticides. An evident increase of intra-alveolar granular staining was noted in most fatalities from mechanical asphyxia and drowning, and some cases of fire death. SP-A staining was usually very weak or sparse in alcohol intoxication, poisoning by hypnotics and also carbon monoxide poisoning. These findings suggest that the amount of intra-alveolar granular SP-A staining may be a possible indicator of severity and duration of respiratory distress (agony) from peripheral (non-central nervous system) origin and alveolar damage. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)193-197
Number of pages5
JournalForensic Science International
Volume113
Issue number1-3
DOIs
Publication statusPublished - 2000 Sep 11
Externally publishedYes

Fingerprint

Apoproteins
Surface-Active Agents
Cause of Death
Autopsy
Immunohistochemistry
Staining and Labeling
Poisoning
Organophosphates
Neurology
Carbon Monoxide
Hypnotics and Sedatives
Carbon Monoxide Poisoning
Pesticides
Alcoholic Intoxication
Hyalin
Muscle
Asphyxia
Fires
Amniotic Fluid
Alcohols

Keywords

  • Forensic pathology
  • Immunohistochemistry
  • Pulmonary surfactant apoprotein A
  • Respiratory distress

ASJC Scopus subject areas

  • Genetics
  • Analytical Chemistry
  • Pathology and Forensic Medicine
  • Psychiatry and Mental health

Cite this

Immunohistochemistry of pulmonary surfactant apoprotein A in forensic autopsy : Reassessment in relation to the causes of death. / Zhu, Bao Li; Ishida, Kaori; Quan, Li; Fujita, Masaki Q; Maeda, Hitoshi.

In: Forensic Science International, Vol. 113, No. 1-3, 11.09.2000, p. 193-197.

Research output: Contribution to journalArticle

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