Abstract
To reassess the immunohistochemical distribution of pulmonary surfactant apoprotein A (SP-A) in relation to the causes of death, 282 forensic autopsy cases were reviewed. The most intense and dense granular immunostaining of intra-alveolar SP-A was observed in the hyaline membrane syndrome from various traumas, protracted death from drowning, and perinatal aspiration of amniotic fluid. Similar granular staining pattern was found in fatal poisoning by a muscle relaxant and organophosphate pesticides. An evident increase of intra-alveolar granular staining was noted in most fatalities from mechanical asphyxia and drowning, and some cases of fire death. SP-A staining was usually very weak or sparse in alcohol intoxication, poisoning by hypnotics and also carbon monoxide poisoning. These findings suggest that the amount of intra-alveolar granular SP-A staining may be a possible indicator of severity and duration of respiratory distress (agony) from peripheral (non-central nervous system) origin and alveolar damage. Copyright (C) 2000 Elsevier Science Ireland Ltd.
| Original language | English |
|---|---|
| Pages (from-to) | 193-197 |
| Number of pages | 5 |
| Journal | Forensic Science International |
| Volume | 113 |
| Issue number | 1-3 |
| DOIs | |
| Publication status | Published - 2000 Sep 11 |
| Externally published | Yes |
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Keywords
- Forensic pathology
- Immunohistochemistry
- Pulmonary surfactant apoprotein A
- Respiratory distress
ASJC Scopus subject areas
- Genetics
- Analytical Chemistry
- Pathology and Forensic Medicine
- Psychiatry and Mental health
Cite this
Immunohistochemistry of pulmonary surfactant apoprotein A in forensic autopsy : Reassessment in relation to the causes of death. / Zhu, Bao Li; Ishida, Kaori; Quan, Li; Fujita, Masaki Q; Maeda, Hitoshi.
In: Forensic Science International, Vol. 113, No. 1-3, 11.09.2000, p. 193-197.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immunohistochemistry of pulmonary surfactant apoprotein A in forensic autopsy
T2 - Reassessment in relation to the causes of death
AU - Zhu, Bao Li
AU - Ishida, Kaori
AU - Quan, Li
AU - Fujita, Masaki Q
AU - Maeda, Hitoshi
PY - 2000/9/11
Y1 - 2000/9/11
N2 - To reassess the immunohistochemical distribution of pulmonary surfactant apoprotein A (SP-A) in relation to the causes of death, 282 forensic autopsy cases were reviewed. The most intense and dense granular immunostaining of intra-alveolar SP-A was observed in the hyaline membrane syndrome from various traumas, protracted death from drowning, and perinatal aspiration of amniotic fluid. Similar granular staining pattern was found in fatal poisoning by a muscle relaxant and organophosphate pesticides. An evident increase of intra-alveolar granular staining was noted in most fatalities from mechanical asphyxia and drowning, and some cases of fire death. SP-A staining was usually very weak or sparse in alcohol intoxication, poisoning by hypnotics and also carbon monoxide poisoning. These findings suggest that the amount of intra-alveolar granular SP-A staining may be a possible indicator of severity and duration of respiratory distress (agony) from peripheral (non-central nervous system) origin and alveolar damage. Copyright (C) 2000 Elsevier Science Ireland Ltd.
AB - To reassess the immunohistochemical distribution of pulmonary surfactant apoprotein A (SP-A) in relation to the causes of death, 282 forensic autopsy cases were reviewed. The most intense and dense granular immunostaining of intra-alveolar SP-A was observed in the hyaline membrane syndrome from various traumas, protracted death from drowning, and perinatal aspiration of amniotic fluid. Similar granular staining pattern was found in fatal poisoning by a muscle relaxant and organophosphate pesticides. An evident increase of intra-alveolar granular staining was noted in most fatalities from mechanical asphyxia and drowning, and some cases of fire death. SP-A staining was usually very weak or sparse in alcohol intoxication, poisoning by hypnotics and also carbon monoxide poisoning. These findings suggest that the amount of intra-alveolar granular SP-A staining may be a possible indicator of severity and duration of respiratory distress (agony) from peripheral (non-central nervous system) origin and alveolar damage. Copyright (C) 2000 Elsevier Science Ireland Ltd.
KW - Forensic pathology
KW - Immunohistochemistry
KW - Pulmonary surfactant apoprotein A
KW - Respiratory distress
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UR - http://www.scopus.com/inward/citedby.url?scp=0343006767&partnerID=8YFLogxK
U2 - 10.1016/S0379-0738(00)00264-4
DO - 10.1016/S0379-0738(00)00264-4
M3 - Article
C2 - 10978624
AN - SCOPUS:0343006767
VL - 113
SP - 193
EP - 197
JO - Forensic Science International
JF - Forensic Science International
SN - 0379-0738
IS - 1-3
ER -