Immunolocalization of vascular adhesion protein-1 in human conjunctival tumors

Junichi Fukuhara; Satoru Kase; Kousuke Noda; Miyuki Murata; Mika Noda; Ryo Ando; Zhenyu Dong; Atsuhiro Kanda; Susumu Ishida

doi:10.1159/000335983

Immunolocalization of vascular adhesion protein-1 in human conjunctival tumors

Junichi Fukuhara, Satoru Kase, Kousuke Noda, Miyuki Murata, Mika Noda, Ryo Ando, Zhenyu Dong, Atsuhiro Kanda, Susumu Ishida

Department of Ophthalmology

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Objective: We analyzed the expression and immunolocalization of vascular adhesion protein (VAP)-1 in conjunctival tumors and normal conjunctival tissue of humans. Methods: Nine conjunctival tumors, including pyogenic granuloma and extranodal marginal zone B-cell lymphoma (EMZL), and 2 normal conjunctivas were analyzed by immunohistochemistry for VAP-1 and CD31 expression. Results: Immunoreactivity for VAP-1 was detected in the lumen of microvessels in pyogenic granuloma and in EMZLs. In contrast, normal bulbar conjunctival tissues demonstrated weak cytoplasmic immunoreactivity for VAP-1 in the blood vessels. Conclusions: The immunolocalization of VAP-1 varied in the histopathology of the conjunctiva, involving the pathology of inflammatory conjunctival disorders.

Original language	English
Pages (from-to)	33-37
Number of pages	5
Journal	Ophthalmic research
Volume	48
Issue number	1
DOIs	https://doi.org/10.1159/000335983
Publication status	Published - 2012 Jun

Keywords

Conjunctiva
Extranodal marginal zone B-cell lymphoma
Pyogenic granuloma
Vascular adhesion protein-1

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

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@article{e418bc22729c49adb617d957424f1f95,

title = "Immunolocalization of vascular adhesion protein-1 in human conjunctival tumors",

abstract = "Objective: We analyzed the expression and immunolocalization of vascular adhesion protein (VAP)-1 in conjunctival tumors and normal conjunctival tissue of humans. Methods: Nine conjunctival tumors, including pyogenic granuloma and extranodal marginal zone B-cell lymphoma (EMZL), and 2 normal conjunctivas were analyzed by immunohistochemistry for VAP-1 and CD31 expression. Results: Immunoreactivity for VAP-1 was detected in the lumen of microvessels in pyogenic granuloma and in EMZLs. In contrast, normal bulbar conjunctival tissues demonstrated weak cytoplasmic immunoreactivity for VAP-1 in the blood vessels. Conclusions: The immunolocalization of VAP-1 varied in the histopathology of the conjunctiva, involving the pathology of inflammatory conjunctival disorders.",

keywords = "Conjunctiva, Extranodal marginal zone B-cell lymphoma, Pyogenic granuloma, Vascular adhesion protein-1",

author = "Junichi Fukuhara and Satoru Kase and Kousuke Noda and Miyuki Murata and Mika Noda and Ryo Ando and Zhenyu Dong and Atsuhiro Kanda and Susumu Ishida",

year = "2012",

month = jun,

doi = "10.1159/000335983",

language = "English",

volume = "48",

pages = "33--37",

journal = "Ophthalmic Research",

issn = "0030-3747",

publisher = "S. Karger AG",

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TY - JOUR

T1 - Immunolocalization of vascular adhesion protein-1 in human conjunctival tumors

AU - Fukuhara, Junichi

AU - Kase, Satoru

AU - Noda, Kousuke

AU - Murata, Miyuki

AU - Noda, Mika

AU - Ando, Ryo

AU - Dong, Zhenyu

AU - Kanda, Atsuhiro

AU - Ishida, Susumu

PY - 2012/6

Y1 - 2012/6

N2 - Objective: We analyzed the expression and immunolocalization of vascular adhesion protein (VAP)-1 in conjunctival tumors and normal conjunctival tissue of humans. Methods: Nine conjunctival tumors, including pyogenic granuloma and extranodal marginal zone B-cell lymphoma (EMZL), and 2 normal conjunctivas were analyzed by immunohistochemistry for VAP-1 and CD31 expression. Results: Immunoreactivity for VAP-1 was detected in the lumen of microvessels in pyogenic granuloma and in EMZLs. In contrast, normal bulbar conjunctival tissues demonstrated weak cytoplasmic immunoreactivity for VAP-1 in the blood vessels. Conclusions: The immunolocalization of VAP-1 varied in the histopathology of the conjunctiva, involving the pathology of inflammatory conjunctival disorders.

AB - Objective: We analyzed the expression and immunolocalization of vascular adhesion protein (VAP)-1 in conjunctival tumors and normal conjunctival tissue of humans. Methods: Nine conjunctival tumors, including pyogenic granuloma and extranodal marginal zone B-cell lymphoma (EMZL), and 2 normal conjunctivas were analyzed by immunohistochemistry for VAP-1 and CD31 expression. Results: Immunoreactivity for VAP-1 was detected in the lumen of microvessels in pyogenic granuloma and in EMZLs. In contrast, normal bulbar conjunctival tissues demonstrated weak cytoplasmic immunoreactivity for VAP-1 in the blood vessels. Conclusions: The immunolocalization of VAP-1 varied in the histopathology of the conjunctiva, involving the pathology of inflammatory conjunctival disorders.

KW - Conjunctiva

KW - Extranodal marginal zone B-cell lymphoma

KW - Pyogenic granuloma

KW - Vascular adhesion protein-1

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