Immunolocalization of vascular adhesion protein-1 in human conjunctival tumors

Junichi Fukuhara, Satoru Kase, Kousuke Noda, Miyuki Murata, Mika Noda, Ryo Ando, Zhenyu Dong, Atsuhiro Kanda, Susumu Ishida

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6 Citations (Scopus)

Abstract

Objective: We analyzed the expression and immunolocalization of vascular adhesion protein (VAP)-1 in conjunctival tumors and normal conjunctival tissue of humans. Methods: Nine conjunctival tumors, including pyogenic granuloma and extranodal marginal zone B-cell lymphoma (EMZL), and 2 normal conjunctivas were analyzed by immunohistochemistry for VAP-1 and CD31 expression. Results: Immunoreactivity for VAP-1 was detected in the lumen of microvessels in pyogenic granuloma and in EMZLs. In contrast, normal bulbar conjunctival tissues demonstrated weak cytoplasmic immunoreactivity for VAP-1 in the blood vessels. Conclusions: The immunolocalization of VAP-1 varied in the histopathology of the conjunctiva, involving the pathology of inflammatory conjunctival disorders.

Original languageEnglish
Pages (from-to)33-37
Number of pages5
JournalOphthalmic research
Volume48
Issue number1
DOIs
Publication statusPublished - 2012 Jun 1

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Keywords

  • Conjunctiva
  • Extranodal marginal zone B-cell lymphoma
  • Pyogenic granuloma
  • Vascular adhesion protein-1

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Fukuhara, J., Kase, S., Noda, K., Murata, M., Noda, M., Ando, R., Dong, Z., Kanda, A., & Ishida, S. (2012). Immunolocalization of vascular adhesion protein-1 in human conjunctival tumors. Ophthalmic research, 48(1), 33-37. https://doi.org/10.1159/000335983