Abstract
Purpose. To study the incidence and prognosis of immunologic rejection of the central graft after limbal allograft transplantation (keratolimbal allograft transplantation [KLAT]) combined with penetrating keratoplasty (PKP). Methods. Endothelial rejection in central penetrating graft after simultaneous KLAT and PKP using the same donor cornea was retrospectively studied. Incidence, reversibility, prognosis, and changes in limbal grafts were examined. Results. Forty-five eyes underwent simultaneous PKP and KLAT. Endothelial rejection of the central graft was found in 16 eyes (35.6%). At last examination, 10 grafts (62.5%) restored clarity after immunosuppressive therapy. During rejection episodes, four eyes showed engorgement of vessels in limbal grafts, which existed before the episodes. Only one eye developed neovascularization with mild edema of the limbal grafts; however, no other limbal grafts showed abnormalities on biomicroscopy. No epithelial changes were noted, and 14 grafts (87.5%) were covered by corneal epithelium after the rejection. Conclusion. Approximately one third of eyes had endothelial rejection in the central graft after simultaneous KLAT and PKP. Abnormalities suggestive of rejection in the limbal grafts were seldom observed in these eyes, suggesting that immunologic response was different in central and limbal grafts.
| Original language | English |
|---|---|
| Pages (from-to) | 149-152 |
| Number of pages | 4 |
| Journal | Cornea |
| Volume | 20 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2001 |
| Externally published | Yes |
Fingerprint
Keywords
- Corneal epithelium
- Keratoplasty
- Limbus
- Rejection
- Stem cells
ASJC Scopus subject areas
- Ophthalmology
Cite this
Immunologic rejection of the central graft after limbal allograft transplantation combined with penetrating keratoplasty. / Shimazaki, Jun; Maruyama, Fumiko; Shimmura, Shigeto; Fujishima, Hiroshi; Tsubota, Kazuo.
In: Cornea, Vol. 20, No. 2, 2001, p. 149-152.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immunologic rejection of the central graft after limbal allograft transplantation combined with penetrating keratoplasty
AU - Shimazaki, Jun
AU - Maruyama, Fumiko
AU - Shimmura, Shigeto
AU - Fujishima, Hiroshi
AU - Tsubota, Kazuo
PY - 2001
Y1 - 2001
N2 - Purpose. To study the incidence and prognosis of immunologic rejection of the central graft after limbal allograft transplantation (keratolimbal allograft transplantation [KLAT]) combined with penetrating keratoplasty (PKP). Methods. Endothelial rejection in central penetrating graft after simultaneous KLAT and PKP using the same donor cornea was retrospectively studied. Incidence, reversibility, prognosis, and changes in limbal grafts were examined. Results. Forty-five eyes underwent simultaneous PKP and KLAT. Endothelial rejection of the central graft was found in 16 eyes (35.6%). At last examination, 10 grafts (62.5%) restored clarity after immunosuppressive therapy. During rejection episodes, four eyes showed engorgement of vessels in limbal grafts, which existed before the episodes. Only one eye developed neovascularization with mild edema of the limbal grafts; however, no other limbal grafts showed abnormalities on biomicroscopy. No epithelial changes were noted, and 14 grafts (87.5%) were covered by corneal epithelium after the rejection. Conclusion. Approximately one third of eyes had endothelial rejection in the central graft after simultaneous KLAT and PKP. Abnormalities suggestive of rejection in the limbal grafts were seldom observed in these eyes, suggesting that immunologic response was different in central and limbal grafts.
AB - Purpose. To study the incidence and prognosis of immunologic rejection of the central graft after limbal allograft transplantation (keratolimbal allograft transplantation [KLAT]) combined with penetrating keratoplasty (PKP). Methods. Endothelial rejection in central penetrating graft after simultaneous KLAT and PKP using the same donor cornea was retrospectively studied. Incidence, reversibility, prognosis, and changes in limbal grafts were examined. Results. Forty-five eyes underwent simultaneous PKP and KLAT. Endothelial rejection of the central graft was found in 16 eyes (35.6%). At last examination, 10 grafts (62.5%) restored clarity after immunosuppressive therapy. During rejection episodes, four eyes showed engorgement of vessels in limbal grafts, which existed before the episodes. Only one eye developed neovascularization with mild edema of the limbal grafts; however, no other limbal grafts showed abnormalities on biomicroscopy. No epithelial changes were noted, and 14 grafts (87.5%) were covered by corneal epithelium after the rejection. Conclusion. Approximately one third of eyes had endothelial rejection in the central graft after simultaneous KLAT and PKP. Abnormalities suggestive of rejection in the limbal grafts were seldom observed in these eyes, suggesting that immunologic response was different in central and limbal grafts.
KW - Corneal epithelium
KW - Keratoplasty
KW - Limbus
KW - Rejection
KW - Stem cells
UR - http://www.scopus.com/inward/record.url?scp=0035110476&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035110476&partnerID=8YFLogxK
U2 - 10.1097/00003226-200103000-00006
DO - 10.1097/00003226-200103000-00006
M3 - Article
VL - 20
SP - 149
EP - 152
JO - Cornea
JF - Cornea
SN - 0277-3740
IS - 2
ER -