Immunologic rejection of the central graft after limbal allograft transplantation combined with penetrating keratoplasty

Jun Shimazaki, Fumiko Maruyama, Shigeto Shimmura, Hiroshi Fujishima, Kazuo Tsubota

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Purpose. To study the incidence and prognosis of immunologic rejection of the central graft after limbal allograft transplantation (keratolimbal allograft transplantation [KLAT]) combined with penetrating keratoplasty (PKP). Methods. Endothelial rejection in central penetrating graft after simultaneous KLAT and PKP using the same donor cornea was retrospectively studied. Incidence, reversibility, prognosis, and changes in limbal grafts were examined. Results. Forty-five eyes underwent simultaneous PKP and KLAT. Endothelial rejection of the central graft was found in 16 eyes (35.6%). At last examination, 10 grafts (62.5%) restored clarity after immunosuppressive therapy. During rejection episodes, four eyes showed engorgement of vessels in limbal grafts, which existed before the episodes. Only one eye developed neovascularization with mild edema of the limbal grafts; however, no other limbal grafts showed abnormalities on biomicroscopy. No epithelial changes were noted, and 14 grafts (87.5%) were covered by corneal epithelium after the rejection. Conclusion. Approximately one third of eyes had endothelial rejection in the central graft after simultaneous KLAT and PKP. Abnormalities suggestive of rejection in the limbal grafts were seldom observed in these eyes, suggesting that immunologic response was different in central and limbal grafts.

Original languageEnglish
Pages (from-to)149-152
Number of pages4
JournalCornea
Volume20
Issue number2
DOIs
Publication statusPublished - 2001
Externally publishedYes

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Penetrating Keratoplasty
Graft Rejection
Allografts
Transplantation
Transplants
Corneal Epithelium
Immunosuppressive Agents
Cornea
Edema
Cohort Studies

Keywords

  • Corneal epithelium
  • Keratoplasty
  • Limbus
  • Rejection
  • Stem cells

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Immunologic rejection of the central graft after limbal allograft transplantation combined with penetrating keratoplasty. / Shimazaki, Jun; Maruyama, Fumiko; Shimmura, Shigeto; Fujishima, Hiroshi; Tsubota, Kazuo.

In: Cornea, Vol. 20, No. 2, 2001, p. 149-152.

Research output: Contribution to journalArticle

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AU - Tsubota, Kazuo

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N2 - Purpose. To study the incidence and prognosis of immunologic rejection of the central graft after limbal allograft transplantation (keratolimbal allograft transplantation [KLAT]) combined with penetrating keratoplasty (PKP). Methods. Endothelial rejection in central penetrating graft after simultaneous KLAT and PKP using the same donor cornea was retrospectively studied. Incidence, reversibility, prognosis, and changes in limbal grafts were examined. Results. Forty-five eyes underwent simultaneous PKP and KLAT. Endothelial rejection of the central graft was found in 16 eyes (35.6%). At last examination, 10 grafts (62.5%) restored clarity after immunosuppressive therapy. During rejection episodes, four eyes showed engorgement of vessels in limbal grafts, which existed before the episodes. Only one eye developed neovascularization with mild edema of the limbal grafts; however, no other limbal grafts showed abnormalities on biomicroscopy. No epithelial changes were noted, and 14 grafts (87.5%) were covered by corneal epithelium after the rejection. Conclusion. Approximately one third of eyes had endothelial rejection in the central graft after simultaneous KLAT and PKP. Abnormalities suggestive of rejection in the limbal grafts were seldom observed in these eyes, suggesting that immunologic response was different in central and limbal grafts.

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