Immunological abnormalities

Hidekata Yasuoka, Masataka Kuwana

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The pathogenesis of Behçet's disease (BD) is still unclear. Both genetic and environmental factors contribute to the onset of BD, although immunological abnormalities are thought to play an important role. Genetics are responsible for autoinflammation and an underlying immunological condition, while the activation of innate and adaptive immune systems are triggered by environmental factors such as bacterial or viral infections. Underlying immunological abnormalities can lead to a unique expression profile of cytokines associated with Th1 or Th17 and induce both cytotoxicity and neutrophil-dependent inflammation, which are involved in the pathogenesis of BD.

Original languageEnglish
Title of host publicationBehçet's Disease: Progress in Recent Years and Unmet Needs for the Future
PublisherNova Science Publishers, Inc.
Pages23-37
Number of pages15
ISBN (Print)9781634829410, 9781634828932
Publication statusPublished - 2015 Jul 1

Keywords

  • 5101 Heavy chain transgenic mouse Chemotaxis
  • Anti-endothelial cell antibodies (AECA)
  • Autoantibodies
  • Autoimmunity
  • Autoinflammation
  • B cells
  • CD25
  • CD4
  • CD4+ t cells
  • Chemokines
  • Dental caries
  • Genome-wide association studies (GWAS)
  • Heat shock protein 60 (HSP60)
  • HLA-A26
  • HLA-B
  • HLA-B51
  • IFN-γ
  • IL-12
  • IL-17
  • IL-23R/IL12RB2
  • IL-6
  • IL-8
  • IL10
  • Macrophages
  • Neutrophil extracellular traps (NETs)
  • Neutrophils
  • NK cells
  • NKT cells
  • Pathergy reaction
  • Reactive oxygen species (ROS)
  • Regulatory t cells (Treg)
  • Streptococcal antigens
  • Streptococcus sanguis
  • T cells
  • Th1
  • Th17
  • TNFα
  • Tonsillitis
  • Vδ1+ t cells
  • αβT cells
  • γδ t cells

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Yasuoka, H., & Kuwana, M. (2015). Immunological abnormalities. In Behçet's Disease: Progress in Recent Years and Unmet Needs for the Future (pp. 23-37). Nova Science Publishers, Inc..