Immunological detection of altered signaling molecules involved in melanoma development

Yutaka Kawakami, Hidetoshi Sumimoto, Tomonobu Fujita, Yuriko Matsuzaki

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

To understand immune responses to human cancer and develop more effective immunotherapy, human tumor antigens has been isolated using various immunological methods with tumor reactive T cells or antibodies obtained from patients with melanoma. During the process of tumor antigen isolation, various molecules with genetic alterations or over-expression in tumor cells, which may be involved in proliferation, differentiation, or survival of various cancer cells, were identified. In melanoma, abnormal molecules with mutations including β -catenin, CDK4, and BRAF, and molecules with increased expression including Survivin, were immunologically detected. Therefore, immunological isolation of human tumor antigens contributes to the identification of important molecules including altered signaling molecules involved in melanoma formation.

Original languageEnglish
Pages (from-to)357-366
Number of pages10
JournalCancer and Metastasis Reviews
Volume24
Issue number2
DOIs
Publication statusPublished - 2005 Jun 1

Keywords

  • BRAF
  • DNA expression cloning
  • Immunotherapy
  • MART-2/Ski
  • Tumor antigens
  • β-catenin

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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