Immunological homeostasis for understanding inflammatory bowel diseases

Takanori Kanai, Mamoru Watanabe

Research output: Contribution to journalArticle

Abstract

Inflammatory bowel diseases are thought to be caused by a complex interaction of genetic, immunological, and environmental factors. The involvement of immunological factors in the etiology of inflammatory bowel diseases is suggested by various facts, such as 1) the effectiveness of immunosuppressive agents, steroids, and anti-TNF-α antibody; 2) the presence of autoantibodies, and 3) the spontaneous development of chronic colitis in mice lacking a single immunity-related gene, e.g., IL-2 or TGF-β. In particular, the treatment of Crohn's disease using anti-TNF-α antibody has been applied to clinical practice with satisfactory clinical results all over the world. This article describes the immunological pathology of inflammatory bowel diseases as autoimmune diseases, and outlines prospective new treatment methods based on the nature of the disease.

Original languageEnglish
Pages (from-to)593-600
Number of pages8
JournalJapan Medical Association Journal
Volume48
Issue number12
Publication statusPublished - 2005 Dec
Externally publishedYes

Fingerprint

Inflammatory Bowel Diseases
Homeostasis
Immunologic Factors
Anti-Idiotypic Antibodies
Colitis
Immunosuppressive Agents
Crohn Disease
Autoantibodies
Autoimmune Diseases
Interleukin-2
Immunity
Steroids
Pathology
Genes

Keywords

  • Colitis
  • Inflammatory bowel diseases
  • Leukocytapheresis
  • Regulatory T cells

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Immunological homeostasis for understanding inflammatory bowel diseases. / Kanai, Takanori; Watanabe, Mamoru.

In: Japan Medical Association Journal, Vol. 48, No. 12, 12.2005, p. 593-600.

Research output: Contribution to journalArticle

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