Immunological suppression after surgery in scoliosis patients

N. Suzuki, O. Kaneko, T. Nakayama, Y. Fukuiya, S. Kuge, Y. Fujimura

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

This is a prospective study to analyze the postoperative immunological changes in scoliosis surgery. Twenty-eight patients who underwent Harrington instrumentation were analyzed. Seven patients who underwent arthroscopic surgery were analyzed as a control group. The objective of this study is to determine whether surgery and surgical stress (minor versus major surgery) changed the immune capability of patients as indicated by the ratio of lymphocyte cell types and interferon induction. Pre- and postoperative blood from scoliosis and knee arthroscopy patients was analyzed at various times using antisera and two-color flow cytometry with monoclonal antibodies. Both scoliosis and knee arthroscopy patients had a postoperative decrease in the population of B-lymphocytes (Leu 12+) and a transient increase in the natural killer cells (Leu 4-/Leu 19+) and the cytotoxic T-lymphocytes (Leu 2a++/Leu 15-). These changes were significantly greater in the scoliosis patients, who also experienced a prolonged decrease in the inducer T-lymphocytes (Leu 8+/Leu 3a+) for 3 weeks following surgery. Production of interferon-α and interferon-γ by lymphocytes was suppressed postoperatively and returned to preoperative levels within 3 weeks. Immunological depressive changes occurred postoperatively and lasted at least 1 week. These effects are more pronounced with longer surgeries, suggesting greater postoperative vigilance for infections in these cases.

Original languageEnglish
Pages (from-to)39-44
Number of pages6
JournalEuropean Spine Journal
Volume6
Issue number1
DOIs
Publication statusPublished - 1997

Fingerprint

Scoliosis
Arthroscopy
Interferons
Knee
Lymphocytes
Population Dynamics
Cytotoxic T-Lymphocytes
Helper-Inducer T-Lymphocytes
Natural Killer Cells
Immune Sera
Flow Cytometry
B-Lymphocytes
Color
Monoclonal Antibodies
Prospective Studies
Control Groups
Infection

Keywords

  • flow cytometry
  • Harrington instrumentation
  • immunoglobulins
  • interferon-α
  • scoliosis

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Suzuki, N., Kaneko, O., Nakayama, T., Fukuiya, Y., Kuge, S., & Fujimura, Y. (1997). Immunological suppression after surgery in scoliosis patients. European Spine Journal, 6(1), 39-44. https://doi.org/10.1007/BF01676573

Immunological suppression after surgery in scoliosis patients. / Suzuki, N.; Kaneko, O.; Nakayama, T.; Fukuiya, Y.; Kuge, S.; Fujimura, Y.

In: European Spine Journal, Vol. 6, No. 1, 1997, p. 39-44.

Research output: Contribution to journalArticle

Suzuki, N, Kaneko, O, Nakayama, T, Fukuiya, Y, Kuge, S & Fujimura, Y 1997, 'Immunological suppression after surgery in scoliosis patients', European Spine Journal, vol. 6, no. 1, pp. 39-44. https://doi.org/10.1007/BF01676573
Suzuki N, Kaneko O, Nakayama T, Fukuiya Y, Kuge S, Fujimura Y. Immunological suppression after surgery in scoliosis patients. European Spine Journal. 1997;6(1):39-44. https://doi.org/10.1007/BF01676573
Suzuki, N. ; Kaneko, O. ; Nakayama, T. ; Fukuiya, Y. ; Kuge, S. ; Fujimura, Y. / Immunological suppression after surgery in scoliosis patients. In: European Spine Journal. 1997 ; Vol. 6, No. 1. pp. 39-44.
@article{8f70fcac4653493e93ca4ebc3dda0ce8,
title = "Immunological suppression after surgery in scoliosis patients",
abstract = "This is a prospective study to analyze the postoperative immunological changes in scoliosis surgery. Twenty-eight patients who underwent Harrington instrumentation were analyzed. Seven patients who underwent arthroscopic surgery were analyzed as a control group. The objective of this study is to determine whether surgery and surgical stress (minor versus major surgery) changed the immune capability of patients as indicated by the ratio of lymphocyte cell types and interferon induction. Pre- and postoperative blood from scoliosis and knee arthroscopy patients was analyzed at various times using antisera and two-color flow cytometry with monoclonal antibodies. Both scoliosis and knee arthroscopy patients had a postoperative decrease in the population of B-lymphocytes (Leu 12+) and a transient increase in the natural killer cells (Leu 4-/Leu 19+) and the cytotoxic T-lymphocytes (Leu 2a++/Leu 15-). These changes were significantly greater in the scoliosis patients, who also experienced a prolonged decrease in the inducer T-lymphocytes (Leu 8+/Leu 3a+) for 3 weeks following surgery. Production of interferon-α and interferon-γ by lymphocytes was suppressed postoperatively and returned to preoperative levels within 3 weeks. Immunological depressive changes occurred postoperatively and lasted at least 1 week. These effects are more pronounced with longer surgeries, suggesting greater postoperative vigilance for infections in these cases.",
keywords = "flow cytometry, Harrington instrumentation, immunoglobulins, interferon-α, scoliosis",
author = "N. Suzuki and O. Kaneko and T. Nakayama and Y. Fukuiya and S. Kuge and Y. Fujimura",
year = "1997",
doi = "10.1007/BF01676573",
language = "English",
volume = "6",
pages = "39--44",
journal = "European Spine Journal",
issn = "0940-6719",
publisher = "Springer Verlag",
number = "1",

}

TY - JOUR

T1 - Immunological suppression after surgery in scoliosis patients

AU - Suzuki, N.

AU - Kaneko, O.

AU - Nakayama, T.

AU - Fukuiya, Y.

AU - Kuge, S.

AU - Fujimura, Y.

PY - 1997

Y1 - 1997

N2 - This is a prospective study to analyze the postoperative immunological changes in scoliosis surgery. Twenty-eight patients who underwent Harrington instrumentation were analyzed. Seven patients who underwent arthroscopic surgery were analyzed as a control group. The objective of this study is to determine whether surgery and surgical stress (minor versus major surgery) changed the immune capability of patients as indicated by the ratio of lymphocyte cell types and interferon induction. Pre- and postoperative blood from scoliosis and knee arthroscopy patients was analyzed at various times using antisera and two-color flow cytometry with monoclonal antibodies. Both scoliosis and knee arthroscopy patients had a postoperative decrease in the population of B-lymphocytes (Leu 12+) and a transient increase in the natural killer cells (Leu 4-/Leu 19+) and the cytotoxic T-lymphocytes (Leu 2a++/Leu 15-). These changes were significantly greater in the scoliosis patients, who also experienced a prolonged decrease in the inducer T-lymphocytes (Leu 8+/Leu 3a+) for 3 weeks following surgery. Production of interferon-α and interferon-γ by lymphocytes was suppressed postoperatively and returned to preoperative levels within 3 weeks. Immunological depressive changes occurred postoperatively and lasted at least 1 week. These effects are more pronounced with longer surgeries, suggesting greater postoperative vigilance for infections in these cases.

AB - This is a prospective study to analyze the postoperative immunological changes in scoliosis surgery. Twenty-eight patients who underwent Harrington instrumentation were analyzed. Seven patients who underwent arthroscopic surgery were analyzed as a control group. The objective of this study is to determine whether surgery and surgical stress (minor versus major surgery) changed the immune capability of patients as indicated by the ratio of lymphocyte cell types and interferon induction. Pre- and postoperative blood from scoliosis and knee arthroscopy patients was analyzed at various times using antisera and two-color flow cytometry with monoclonal antibodies. Both scoliosis and knee arthroscopy patients had a postoperative decrease in the population of B-lymphocytes (Leu 12+) and a transient increase in the natural killer cells (Leu 4-/Leu 19+) and the cytotoxic T-lymphocytes (Leu 2a++/Leu 15-). These changes were significantly greater in the scoliosis patients, who also experienced a prolonged decrease in the inducer T-lymphocytes (Leu 8+/Leu 3a+) for 3 weeks following surgery. Production of interferon-α and interferon-γ by lymphocytes was suppressed postoperatively and returned to preoperative levels within 3 weeks. Immunological depressive changes occurred postoperatively and lasted at least 1 week. These effects are more pronounced with longer surgeries, suggesting greater postoperative vigilance for infections in these cases.

KW - flow cytometry

KW - Harrington instrumentation

KW - immunoglobulins

KW - interferon-α

KW - scoliosis

UR - http://www.scopus.com/inward/record.url?scp=0030984616&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030984616&partnerID=8YFLogxK

U2 - 10.1007/BF01676573

DO - 10.1007/BF01676573

M3 - Article

C2 - 9093826

AN - SCOPUS:0030984616

VL - 6

SP - 39

EP - 44

JO - European Spine Journal

JF - European Spine Journal

SN - 0940-6719

IS - 1

ER -