Immunomodulatory Effects of Drugs for Effective Cancer Immunotherapy

Maiko Matsushita, Mai Kawaguchi

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Recent advances in cancer immunotherapy, including immune checkpoint inhibitors or adoptive T cell therapies, have contributed to better outcomes in cancer patients. However, there are still many cancers with no cure. Therefore, combinations of several treatment strategies are being explored, and enhancing anticancer immunity will play an important role to combat the disease. There have been several reports on the immune-modulatory effects of commonly used drugs, namely, statin, metformin, and angiotensin receptor blockers (ARBs), which suggest that these drugs could enhance immunity against cancer cells. Other anticancer drugs, such as anthracyclines, thalidomides, lenalidomides, and hypomethylating drugs, could also strengthen the immune system to attack cancer cells at a relatively low dose. Hence, these drugs might contribute to better outcomes in cancer patients.

Original languageEnglish
Article number8653489
JournalJournal of Oncology
Volume2018
DOIs
Publication statusPublished - 2018 Jan 1

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Immunotherapy
Pharmaceutical Preparations
Neoplasms
Immunity
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Angiotensin Receptor Antagonists
Metformin
Anthracyclines
Cell- and Tissue-Based Therapy
Immune System
T-Lymphocytes

ASJC Scopus subject areas

  • Oncology

Cite this

Immunomodulatory Effects of Drugs for Effective Cancer Immunotherapy. / Matsushita, Maiko; Kawaguchi, Mai.

In: Journal of Oncology, Vol. 2018, 8653489, 01.01.2018.

Research output: Contribution to journalReview article

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