Immunoregulation by the gut microbiota

Junko Nishio, Kenya Honda

Research output: Contribution to journalReview article

44 Citations (Scopus)

Abstract

The human intestinal mucosa is constantly exposed to commensal microbiota. Since the gut microbiota is beneficial to the host, hosts have evolved intestinespecific immune systems to co-exist with the microbiota. On the other hand, the intestinal microbiota actively regulates the host's immune system, and recent studies have revealed that specific commensal bacterial species induce the accumulation of specific immune cell populations. For instance, segmented filamentous bacteria and Clostridium species belonging to clusters XIVa and IV induce the accumulation of Th17 cells in the small intestine and Foxp3? regulatory T cells in the large intestine, respectively. The immune cells induced by the gut microbiota likely contribute to intestinal homeostasis and influence systemic immunity in the host.

Original languageEnglish
Pages (from-to)3635-3650
Number of pages16
JournalCellular and Molecular Life Sciences
Volume69
Issue number21
DOIs
Publication statusPublished - 2012 Nov

Keywords

  • Clostiridium
  • Gut microbiota
  • Innate lymphoid cells
  • Regulatory T cells
  • Segmented filamentous bacteria
  • Th17

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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