Immunoregulation by the gut microbiota

Junko Nishio, Kenya Honda

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The human intestinal mucosa is constantly exposed to commensal microbiota. Since the gut microbiota is beneficial to the host, hosts have evolved intestinespecific immune systems to co-exist with the microbiota. On the other hand, the intestinal microbiota actively regulates the host's immune system, and recent studies have revealed that specific commensal bacterial species induce the accumulation of specific immune cell populations. For instance, segmented filamentous bacteria and Clostridium species belonging to clusters XIVa and IV induce the accumulation of Th17 cells in the small intestine and Foxp3? regulatory T cells in the large intestine, respectively. The immune cells induced by the gut microbiota likely contribute to intestinal homeostasis and influence systemic immunity in the host.

Original languageEnglish
Pages (from-to)3635-3650
Number of pages16
JournalCellular and Molecular Life Sciences
Volume69
Issue number21
DOIs
Publication statusPublished - 2012 Nov
Externally publishedYes

Fingerprint

Microbiota
Immune System
Th17 Cells
Clostridium
Large Intestine
Regulatory T-Lymphocytes
Intestinal Mucosa
Small Intestine
Immunity
Homeostasis
Bacteria
Population
Gastrointestinal Microbiome

Keywords

  • Clostiridium
  • Gut microbiota
  • Innate lymphoid cells
  • Regulatory T cells
  • Segmented filamentous bacteria
  • Th17

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Molecular Medicine
  • Pharmacology
  • Cellular and Molecular Neuroscience

Cite this

Immunoregulation by the gut microbiota. / Nishio, Junko; Honda, Kenya.

In: Cellular and Molecular Life Sciences, Vol. 69, No. 21, 11.2012, p. 3635-3650.

Research output: Contribution to journalArticle

Nishio, Junko ; Honda, Kenya. / Immunoregulation by the gut microbiota. In: Cellular and Molecular Life Sciences. 2012 ; Vol. 69, No. 21. pp. 3635-3650.
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