Immunoregulation by the gut microbiota

Junko Nishio, Kenya Honda

Research output: Contribution to journalReview articlepeer-review

57 Citations (Scopus)


The human intestinal mucosa is constantly exposed to commensal microbiota. Since the gut microbiota is beneficial to the host, hosts have evolved intestinespecific immune systems to co-exist with the microbiota. On the other hand, the intestinal microbiota actively regulates the host's immune system, and recent studies have revealed that specific commensal bacterial species induce the accumulation of specific immune cell populations. For instance, segmented filamentous bacteria and Clostridium species belonging to clusters XIVa and IV induce the accumulation of Th17 cells in the small intestine and Foxp3? regulatory T cells in the large intestine, respectively. The immune cells induced by the gut microbiota likely contribute to intestinal homeostasis and influence systemic immunity in the host.

Original languageEnglish
Pages (from-to)3635-3650
Number of pages16
JournalCellular and Molecular Life Sciences
Issue number21
Publication statusPublished - 2012 Nov
Externally publishedYes


  • Clostiridium
  • Gut microbiota
  • Innate lymphoid cells
  • Regulatory T cells
  • Segmented filamentous bacteria
  • Th17

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology


Dive into the research topics of 'Immunoregulation by the gut microbiota'. Together they form a unique fingerprint.

Cite this