Immunostimulating activity of celosian, an antihepatotoxic polysaccharide isolated from Celosia argentea

Kouji Hase, Purusotam Basnet, Shigetoshi Kadota, Tsuneo Namba

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Celosian, an acidic polysaccharide from the seeds of Celosia argentea (Amaranthaceae) was found to be a potent antihepatotoxic agent for chemical and immunological liver injury models in animals. The immunomodulating action of celosian was studied to clarify the preventive mechanism of celosian on liver injuries. Celosian induced tumor necrosis factor-α (TNF-α) production in mice. Celosian also induced the production of interleukin-1β (IL-1β) and nitric oxide (NO) in macrophage cell line J774.1 in a concentration-dependent manner (1 to 1000/μg/ml). Moreover, celosian induced IL-1β secretion in human mononuclear cells. In addition, celosian enhanced gamma interferon (IFN-υ) production activity of concanavalin A (Con A) in mice spleen cells, though celosian alone did not significantly influence IFN-υ production. These results indicate that celosian is an immunostimulating agent in addition to antihepatotoxic effects.

Original languageEnglish
Pages (from-to)216-219
Number of pages4
JournalPlanta Medica
Volume63
Issue number3
DOIs
Publication statusPublished - 1997
Externally publishedYes

Fingerprint

Celosia
Celosia argentea
interleukin-1
Polysaccharides
polysaccharides
liver
tumor necrosis factors
Amaranthaceae
mice
production economics
interferons
concanavalin A
splenocytes
interferon-gamma
nitric oxide
macrophages
animal models
cell lines
secretion
seeds

Keywords

  • Amaranthaceae
  • Celosia argentea
  • Celosian
  • Interferon-γ
  • Interleukin- 1β
  • Nitric oxide

ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Immunostimulating activity of celosian, an antihepatotoxic polysaccharide isolated from Celosia argentea. / Hase, Kouji; Basnet, Purusotam; Kadota, Shigetoshi; Namba, Tsuneo.

In: Planta Medica, Vol. 63, No. 3, 1997, p. 216-219.

Research output: Contribution to journalArticle

Hase, Kouji ; Basnet, Purusotam ; Kadota, Shigetoshi ; Namba, Tsuneo. / Immunostimulating activity of celosian, an antihepatotoxic polysaccharide isolated from Celosia argentea. In: Planta Medica. 1997 ; Vol. 63, No. 3. pp. 216-219.
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