Immunotherapy using human melanoma epitopes recognized by T cells

Y. Kawakami

Research output: Contribution to journalArticle

Abstract

Tumor reactive T cells can be induced from peripheral blood or tumor infiltrating lymphocytes of patients with melanoma. Based on the analysis of the previous immunotherapies, T cells appeared to be involved in vivo tumor regression. Genes encoding human melanoma antigens and their epitope peptides recognized by T cells, have been identified using cDNA expression cloning techniques. Mechanisms for generation of T cell epitopes on growing melanoma cells have been identified. A variety of Phase I clinical studies using MART- 1 and gp100 antigens are being performed in the Surgery Branch, National Cancer Institute, NIH, and some patients have responded to these immunotherapy protocols.

Original languageEnglish
Pages (from-to)542-548
Number of pages7
JournalBiotherapy
Volume12
Issue number5
Publication statusPublished - 1998 Jan 1

Keywords

  • Dendritic cells
  • Gp100
  • MART-1
  • Melanoma
  • T cells
  • Tumor antigens

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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