Impact of a donor source on adult philadelphia chromosome-negative acute lymphoblastic leukemia

A retrospective analysis from the adult acute lymphoblastic leukemia working group of the japan society for hematopoietic cell transplantation

S. Nishiwaki, K. Miyamura, K. Ohashi, M. Kurokawa, S. Taniguchi, T. Fukuda, K. Ikegame, S. Takahashi, Takehiko Mori, K. Imai, H. Iida, M. Hidaka, H. Sakamaki, Y. Morishima, K. Kato, R. Suzuki, J. Tanaka

Research output: Contribution to journalArticle

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Abstract

Background: We aimed to clarify the impact of the donor source of allogeneic stem cell transplantation (allo-SCT) on Philadelphia chromosome-negative acute lymphoblastic leukemia [Ph(-) ALL] with focus on cord blood (CB). Patients and methods: We retrospectively analyzed data of 1726 patients who underwent myeloablative allo-SCT for adult Ph(-) ALL. The sources of the allo-SCT were related donors (RD; N = 684), unrelated donors (URD; N = 809), and CB (N = 233). Results: Overall survival (OS) in patients after CB allo-SCT in first complete remission (CR1) was comparable with that after RD or URD allo-SCT (RD: 65%, URD: 64% and CB: 57% at 4 years, P = 0.11). CB was not a significant risk factor for relapse or non-relapse mortality as well as for OS in multivariate analyses. Similarly, the donor source was not a significant risk factor for OS in subsequent CR or non-CR (RD: 47%, URD: 39% and CB: 48% in subsequent CR, P = 0.33; RD: 15%, URD: 21% and CB: 18% in non-CR, P = 0.20 at 4 years). Conclusion: Allo-SCT using CB led to OS similar to those of RD or URD in any disease status. To avoid missing the appropriate timing, CB is a favorable alternative source for adult Ph(-) ALL patients without a suitable RD or URD.

Original languageEnglish
Pages (from-to)1594-1602
Number of pages9
JournalAnnals of Oncology
Volume24
Issue number6
DOIs
Publication statusPublished - 2013 Jun

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Philadelphia Chromosome
Cell Transplantation
Fetal Blood
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Japan
Tissue Donors
Stem Cell Transplantation
Survival
Cord Blood Stem Cell Transplantation
Unrelated Donors
Multivariate Analysis
Recurrence
Mortality

Keywords

  • Allogeneic stem cell transplantation
  • Cord blood
  • Donor source
  • Philadelphia chromosome-negative acute lymphoblastic leukemia

ASJC Scopus subject areas

  • Oncology
  • Hematology

Cite this

Impact of a donor source on adult philadelphia chromosome-negative acute lymphoblastic leukemia : A retrospective analysis from the adult acute lymphoblastic leukemia working group of the japan society for hematopoietic cell transplantation. / Nishiwaki, S.; Miyamura, K.; Ohashi, K.; Kurokawa, M.; Taniguchi, S.; Fukuda, T.; Ikegame, K.; Takahashi, S.; Mori, Takehiko; Imai, K.; Iida, H.; Hidaka, M.; Sakamaki, H.; Morishima, Y.; Kato, K.; Suzuki, R.; Tanaka, J.

In: Annals of Oncology, Vol. 24, No. 6, 06.2013, p. 1594-1602.

Research output: Contribution to journalArticle

Nishiwaki, S, Miyamura, K, Ohashi, K, Kurokawa, M, Taniguchi, S, Fukuda, T, Ikegame, K, Takahashi, S, Mori, T, Imai, K, Iida, H, Hidaka, M, Sakamaki, H, Morishima, Y, Kato, K, Suzuki, R & Tanaka, J 2013, 'Impact of a donor source on adult philadelphia chromosome-negative acute lymphoblastic leukemia: A retrospective analysis from the adult acute lymphoblastic leukemia working group of the japan society for hematopoietic cell transplantation', Annals of Oncology, vol. 24, no. 6, pp. 1594-1602. https://doi.org/10.1093/annonc/mds655
Nishiwaki, S. ; Miyamura, K. ; Ohashi, K. ; Kurokawa, M. ; Taniguchi, S. ; Fukuda, T. ; Ikegame, K. ; Takahashi, S. ; Mori, Takehiko ; Imai, K. ; Iida, H. ; Hidaka, M. ; Sakamaki, H. ; Morishima, Y. ; Kato, K. ; Suzuki, R. ; Tanaka, J. / Impact of a donor source on adult philadelphia chromosome-negative acute lymphoblastic leukemia : A retrospective analysis from the adult acute lymphoblastic leukemia working group of the japan society for hematopoietic cell transplantation. In: Annals of Oncology. 2013 ; Vol. 24, No. 6. pp. 1594-1602.
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title = "Impact of a donor source on adult philadelphia chromosome-negative acute lymphoblastic leukemia: A retrospective analysis from the adult acute lymphoblastic leukemia working group of the japan society for hematopoietic cell transplantation",
abstract = "Background: We aimed to clarify the impact of the donor source of allogeneic stem cell transplantation (allo-SCT) on Philadelphia chromosome-negative acute lymphoblastic leukemia [Ph(-) ALL] with focus on cord blood (CB). Patients and methods: We retrospectively analyzed data of 1726 patients who underwent myeloablative allo-SCT for adult Ph(-) ALL. The sources of the allo-SCT were related donors (RD; N = 684), unrelated donors (URD; N = 809), and CB (N = 233). Results: Overall survival (OS) in patients after CB allo-SCT in first complete remission (CR1) was comparable with that after RD or URD allo-SCT (RD: 65{\%}, URD: 64{\%} and CB: 57{\%} at 4 years, P = 0.11). CB was not a significant risk factor for relapse or non-relapse mortality as well as for OS in multivariate analyses. Similarly, the donor source was not a significant risk factor for OS in subsequent CR or non-CR (RD: 47{\%}, URD: 39{\%} and CB: 48{\%} in subsequent CR, P = 0.33; RD: 15{\%}, URD: 21{\%} and CB: 18{\%} in non-CR, P = 0.20 at 4 years). Conclusion: Allo-SCT using CB led to OS similar to those of RD or URD in any disease status. To avoid missing the appropriate timing, CB is a favorable alternative source for adult Ph(-) ALL patients without a suitable RD or URD.",
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T1 - Impact of a donor source on adult philadelphia chromosome-negative acute lymphoblastic leukemia

T2 - A retrospective analysis from the adult acute lymphoblastic leukemia working group of the japan society for hematopoietic cell transplantation

AU - Nishiwaki, S.

AU - Miyamura, K.

AU - Ohashi, K.

AU - Kurokawa, M.

AU - Taniguchi, S.

AU - Fukuda, T.

AU - Ikegame, K.

AU - Takahashi, S.

AU - Mori, Takehiko

AU - Imai, K.

AU - Iida, H.

AU - Hidaka, M.

AU - Sakamaki, H.

AU - Morishima, Y.

AU - Kato, K.

AU - Suzuki, R.

AU - Tanaka, J.

PY - 2013/6

Y1 - 2013/6

N2 - Background: We aimed to clarify the impact of the donor source of allogeneic stem cell transplantation (allo-SCT) on Philadelphia chromosome-negative acute lymphoblastic leukemia [Ph(-) ALL] with focus on cord blood (CB). Patients and methods: We retrospectively analyzed data of 1726 patients who underwent myeloablative allo-SCT for adult Ph(-) ALL. The sources of the allo-SCT were related donors (RD; N = 684), unrelated donors (URD; N = 809), and CB (N = 233). Results: Overall survival (OS) in patients after CB allo-SCT in first complete remission (CR1) was comparable with that after RD or URD allo-SCT (RD: 65%, URD: 64% and CB: 57% at 4 years, P = 0.11). CB was not a significant risk factor for relapse or non-relapse mortality as well as for OS in multivariate analyses. Similarly, the donor source was not a significant risk factor for OS in subsequent CR or non-CR (RD: 47%, URD: 39% and CB: 48% in subsequent CR, P = 0.33; RD: 15%, URD: 21% and CB: 18% in non-CR, P = 0.20 at 4 years). Conclusion: Allo-SCT using CB led to OS similar to those of RD or URD in any disease status. To avoid missing the appropriate timing, CB is a favorable alternative source for adult Ph(-) ALL patients without a suitable RD or URD.

AB - Background: We aimed to clarify the impact of the donor source of allogeneic stem cell transplantation (allo-SCT) on Philadelphia chromosome-negative acute lymphoblastic leukemia [Ph(-) ALL] with focus on cord blood (CB). Patients and methods: We retrospectively analyzed data of 1726 patients who underwent myeloablative allo-SCT for adult Ph(-) ALL. The sources of the allo-SCT were related donors (RD; N = 684), unrelated donors (URD; N = 809), and CB (N = 233). Results: Overall survival (OS) in patients after CB allo-SCT in first complete remission (CR1) was comparable with that after RD or URD allo-SCT (RD: 65%, URD: 64% and CB: 57% at 4 years, P = 0.11). CB was not a significant risk factor for relapse or non-relapse mortality as well as for OS in multivariate analyses. Similarly, the donor source was not a significant risk factor for OS in subsequent CR or non-CR (RD: 47%, URD: 39% and CB: 48% in subsequent CR, P = 0.33; RD: 15%, URD: 21% and CB: 18% in non-CR, P = 0.20 at 4 years). Conclusion: Allo-SCT using CB led to OS similar to those of RD or URD in any disease status. To avoid missing the appropriate timing, CB is a favorable alternative source for adult Ph(-) ALL patients without a suitable RD or URD.

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KW - Cord blood

KW - Donor source

KW - Philadelphia chromosome-negative acute lymphoblastic leukemia

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DO - 10.1093/annonc/mds655

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