Impact of a novel smartphone app (cureapp smoking cessation) on nicotine dependence: Prospective single-arm interventional pilot study

Katsunori Masaki, Hiroki Tateno, Naofumi Kameyama, Eriko Morino, Riri Watanabe, Kazuma Sekine, Tomohiro Ono, Kohta Satake, Shin Suzuki, Akihiro Nomura, Tomoko Betsuyaku, Koichi Fukunaga

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Mobile apps have been considered to provide active and continuous support for smoking cessation. However, it is yet to be known whether a smoking cessation smartphone app improves long-term abstinence rates in nicotine-dependent patients. Objective: This study aimed to evaluate the long-term abstinence effect of a novel smartphone app, CureApp Smoking Cessation (CASC), in patients with nicotine dependence. Methods: In this prospective, interventional, multicenter, single-arm study, we provided the CASC app to all the participants, who used it daily for 24 weeks. The CASC app includes features to maximize the therapeutic effect of pharmacological therapies and counseling at outpatient clinics for smoking cessation. The primary endpoint was a continuous abstinence rate (CAR) from weeks 9 to 24, whereas secondary endpoints were CARs from weeks 9 to 12 and 9 to 52. Results: Of the 56 adult smokers recruited, 1 did not download the app; therefore, 55 participants constituted the full analysis sample. The CAR from weeks 9 to 24 was 64% (35/55, 95% CI 51%-76%), whereas the CARs from weeks 9 to 12 and 9 to 52 were 76% (42/55, 95% CI 65%-88%) and 58% (32/55, 95% CI 46%-71%), respectively. These CARs were better than the results of the national survey on outpatient clinics with regard to smoking cessation under the National Health Insurance Program and that of the varenicline phase 3 trial in Japan and the United States. There was only 1 participant who dropped out during the 12 weeks of the treatment period. This treatment decreased the scores related to withdrawal and craving symptoms. Conclusions: The addition of CASC to usual smoking cessation therapies resulted in high CARs, high patient retention rates, and improvement of cessation-related symptoms. The smartphone app CASC is a feasible and useful tool to help long-term continuous abstinence that can be combined with a standard smoking cessation treatment program.

Original languageEnglish
Article numbere12694
JournalJournal of medical Internet research
Volume21
Issue number2
DOIs
Publication statusPublished - 2019 Feb 1

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Tobacco Use Disorder
Smoking Cessation
National Health Programs
Ambulatory Care Facilities
Smartphone
Mobile Applications
Substance Withdrawal Syndrome
Withholding Treatment
Therapeutic Uses
Therapeutics
Nicotine
Counseling
Japan
Pharmacology

Keywords

  • Digital therapeutics
  • Nicotine dependence
  • Smartphone application
  • Smoking cessation
  • Telemedicine

ASJC Scopus subject areas

  • Health Informatics

Cite this

Impact of a novel smartphone app (cureapp smoking cessation) on nicotine dependence : Prospective single-arm interventional pilot study. / Masaki, Katsunori; Tateno, Hiroki; Kameyama, Naofumi; Morino, Eriko; Watanabe, Riri; Sekine, Kazuma; Ono, Tomohiro; Satake, Kohta; Suzuki, Shin; Nomura, Akihiro; Betsuyaku, Tomoko; Fukunaga, Koichi.

In: Journal of medical Internet research, Vol. 21, No. 2, e12694, 01.02.2019.

Research output: Contribution to journalArticle

Masaki, K, Tateno, H, Kameyama, N, Morino, E, Watanabe, R, Sekine, K, Ono, T, Satake, K, Suzuki, S, Nomura, A, Betsuyaku, T & Fukunaga, K 2019, 'Impact of a novel smartphone app (cureapp smoking cessation) on nicotine dependence: Prospective single-arm interventional pilot study', Journal of medical Internet research, vol. 21, no. 2, e12694. https://doi.org/10.2196/12694
Masaki, Katsunori ; Tateno, Hiroki ; Kameyama, Naofumi ; Morino, Eriko ; Watanabe, Riri ; Sekine, Kazuma ; Ono, Tomohiro ; Satake, Kohta ; Suzuki, Shin ; Nomura, Akihiro ; Betsuyaku, Tomoko ; Fukunaga, Koichi. / Impact of a novel smartphone app (cureapp smoking cessation) on nicotine dependence : Prospective single-arm interventional pilot study. In: Journal of medical Internet research. 2019 ; Vol. 21, No. 2.
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abstract = "Background: Mobile apps have been considered to provide active and continuous support for smoking cessation. However, it is yet to be known whether a smoking cessation smartphone app improves long-term abstinence rates in nicotine-dependent patients. Objective: This study aimed to evaluate the long-term abstinence effect of a novel smartphone app, CureApp Smoking Cessation (CASC), in patients with nicotine dependence. Methods: In this prospective, interventional, multicenter, single-arm study, we provided the CASC app to all the participants, who used it daily for 24 weeks. The CASC app includes features to maximize the therapeutic effect of pharmacological therapies and counseling at outpatient clinics for smoking cessation. The primary endpoint was a continuous abstinence rate (CAR) from weeks 9 to 24, whereas secondary endpoints were CARs from weeks 9 to 12 and 9 to 52. Results: Of the 56 adult smokers recruited, 1 did not download the app; therefore, 55 participants constituted the full analysis sample. The CAR from weeks 9 to 24 was 64{\%} (35/55, 95{\%} CI 51{\%}-76{\%}), whereas the CARs from weeks 9 to 12 and 9 to 52 were 76{\%} (42/55, 95{\%} CI 65{\%}-88{\%}) and 58{\%} (32/55, 95{\%} CI 46{\%}-71{\%}), respectively. These CARs were better than the results of the national survey on outpatient clinics with regard to smoking cessation under the National Health Insurance Program and that of the varenicline phase 3 trial in Japan and the United States. There was only 1 participant who dropped out during the 12 weeks of the treatment period. This treatment decreased the scores related to withdrawal and craving symptoms. Conclusions: The addition of CASC to usual smoking cessation therapies resulted in high CARs, high patient retention rates, and improvement of cessation-related symptoms. The smartphone app CASC is a feasible and useful tool to help long-term continuous abstinence that can be combined with a standard smoking cessation treatment program.",
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AU - Kameyama, Naofumi

AU - Morino, Eriko

AU - Watanabe, Riri

AU - Sekine, Kazuma

AU - Ono, Tomohiro

AU - Satake, Kohta

AU - Suzuki, Shin

AU - Nomura, Akihiro

AU - Betsuyaku, Tomoko

AU - Fukunaga, Koichi

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